2017
Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway
Charkoftaki G, Jester JV, Thompson DC, Vasiliou V. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. The Ocular Surface 2017, 16: 154-162. PMID: 29129753, PMCID: PMC7376578, DOI: 10.1016/j.jtos.2017.11.004.Peer-Reviewed Original ResearchConceptsCorneal damageNM exposureSphingomyelin-ceramide pathwayCorneal stromaIrreversible corneal damageNitrogen mustardAltered lipid profileSulfur mustardCorneal injuryLipid profileCentral corneaCorneal epitheliumRabbit eyesSpecific sphingomyelinsPotent vesicantCorneaOrgan cultureStromaLipidomic analysisExposureMorphological changesDamaging effectsDamageInjuryPathway
2012
Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal
Black W, Chen Y, Matsumoto A, Thompson DC, Lassen N, Pappa A, Vasiliou V. Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radical Biology And Medicine 2012, 52: 1937-1944. PMID: 22406320, PMCID: PMC3457646, DOI: 10.1016/j.freeradbiomed.2012.02.050.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenasesOxidative stress responseCellular defense mechanismsOxidative stressHuman ALDH3A1Proteasome functionMolecular mechanismsPrevents apoptosisStress responseCellular protectionLipid peroxidationAdverse effectsWestern blot analysisAldehydic moleculesGlutathione homeostasisALDH3A1 expressionCell viability assaysMetabolic functionsALDH3A1Blot analysisDefense mechanismsProtein adduct formationCell linesCell viabilityViability assays
1994
Characterization of acetylcholinesterase in rabbit intrapulmonary arteries
Altiere R, Travis D, Thompson D. Characterization of acetylcholinesterase in rabbit intrapulmonary arteries. American Journal Of Physiology 1994, 267: l745-l752. PMID: 7810679, DOI: 10.1152/ajplung.1994.267.6.l745.Peer-Reviewed Original ResearchConceptsAction of acetylcholinePulmonary blood vesselsCholinesterase activityLobar arteryIntrapulmonary arteriesBlood vesselsRabbit intrapulmonary arteriesACh-induced contractionConcentration-dependent inhibitionPulmonary arteryIntrapulmonary veinsPulmonary vasculatureTrachealis muscleMicroM neostigminePeripheral tissuesArteryEnzyme activityAcetylcholineCholinesterase inhibitionArterial enzymeSelective inhibitorMin/NeostigmineAortaCholinesterase enzymesPharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries.
Altiere R, Travis D, Roberts J, Thompson D. Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries. Journal Of Pharmacology And Experimental Therapeutics 1994, 270: 269-76. PMID: 8035325.Peer-Reviewed Original ResearchConceptsRelaxant responsesPA2 valuesContractile responsePulmonary arteryMuscarinic receptorsM1-selective antagonist pirenzepineEndothelium-dependent contractionsRabbit intrapulmonary arteriesEndothelium-dependent relaxationIsolated pulmonary arteriesM3-selective antagonistRabbit pulmonary arteryAcetylcholine-induced contractionsMuscarinic receptor subtypesN-methylpiperidine methiodideM2-selective antagonistSubtype-selective antagonistsNitric oxide synthaseInhibitor of cyclooxygenaseElevated toneAntagonist pirenzepineIntrapulmonary arteriesOxide synthaseReceptor subtypesPharmacological characterization
1992
Modulation of cholinergic responses by Nω-nitro-l-arginine in rabbit intrapulmonary arteries
Altiere R, Thompson D. Modulation of cholinergic responses by Nω-nitro-l-arginine in rabbit intrapulmonary arteries. Pulmonary Pharmacology & Therapeutics 1992, 5: 149-151. PMID: 1611234, DOI: 10.1016/0952-0600(92)90034-e.Peer-Reviewed Original Research