Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response
Liu S, Iorgulescu J, Li S, Borji M, Barrera-Lopez I, Shanmugam V, Lyu H, Morriss J, Garcia Z, Murray E, Reardon D, Yoon C, Braun D, Livak K, Wu C, Chen F. Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response. Immunity 2022, 55: 1940-1952.e5. PMID: 36223726, PMCID: PMC9745674, DOI: 10.1016/j.immuni.2022.09.002.Peer-Reviewed Original ResearchConceptsImmune responseTCR repertoireAntigen-specific immune responsesCell receptorDistinct TCR repertoireAdaptive immune responsesLymphoid germinal centersRenal cell carcinomaHeterogeneous immune responseCell carcinomaImmune cellsCell clonotypesT cellsImmune nichesAdjacent tumorGerminal centersMelanoma specimensCell responsesMouse spleenDistinct gene expressionGene expressionReceptorsCharacteristic locationCell typesCells