2017
Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis
Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL. Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis. Journal Of Clinical Gastroenterology 2017, 51: e11-e16. PMID: 27428727, PMCID: PMC5218875, DOI: 10.1097/mcg.0000000000000591.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAlanine TransaminaseAlkaline PhosphataseBile Acids and SaltsCholagogues and CholereticsCholangitis, SclerosingCholestenonesDrug Therapy, CombinationFemaleHumansLiverLiver Function TestsMaleMiddle AgedPilot ProjectsTreatment OutcomeTretinoinUrsodeoxycholic AcidYoung AdultConceptsPrimary sclerosing cholangitisUrsodeoxycholic acidAlanine aminotransferaseUDCA monotherapyPrimary endpointSclerosing cholangitisMedian serum alanine aminotransferasePilot studyWeeks of therapyMarkers of inflammationSerum alanine aminotransferaseRetinoic acidAlkaline phosphataseAll-Trans Retinoic AcidSerum ALP levelsHuman pilot studyCombination of ATRAAddition of ATRABile acid synthesisTrans retinoic acidExploratory pilot studyALT levelsAccepted therapyWeek 12C4 levels
2016
A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients
Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Digestive Diseases And Sciences 2016, 61: 3506-3512. PMID: 27696094, PMCID: PMC5106299, DOI: 10.1007/s10620-016-4322-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAdultAlanine TransaminaseAntigens, Differentiation, B-LymphocyteAsian PeopleCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseHepatitis, AutoimmuneHistocompatibility Antigens Class IIHumansIntramolecular OxidoreductasesJapanMacrophage Migration-Inhibitory FactorsMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideSeverity of Illness IndexUnited StatesConceptsMacrophage migration inhibitory factorAIH patientsAutoimmune hepatitisSteroid requirementsMIF expressionMacrophage Migration Inhibitory Factor PolymorphismGC/CC genotypesCC/GCJapanese AIH patientsJapanese patient groupMigration inhibitory factorMultiple autoimmune diseasesGC single nucleotide polymorphismsGC/CCAIH groupHepatitis severityMIF promoterSteroid resistanceMIF genotypeSerum ALTSymptomatic presentationGG patientsHigher ALTClinical parametersMIF polymorphisms