A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients
Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R. A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Digestive Diseases And Sciences 2016, 61: 3506-3512. PMID: 27696094, PMCID: PMC5106299, DOI: 10.1007/s10620-016-4322-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAdultAlanine TransaminaseAntigens, Differentiation, B-LymphocyteAsian PeopleCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseHepatitis, AutoimmuneHistocompatibility Antigens Class IIHumansIntramolecular OxidoreductasesJapanMacrophage Migration-Inhibitory FactorsMaleMiddle AgedPolymorphism, GeneticPolymorphism, Single NucleotideSeverity of Illness IndexUnited StatesConceptsMacrophage migration inhibitory factorAIH patientsAutoimmune hepatitisSteroid requirementsMIF expressionMacrophage Migration Inhibitory Factor PolymorphismGC/CC genotypesCC/GCJapanese AIH patientsJapanese patient groupMigration inhibitory factorMultiple autoimmune diseasesGC single nucleotide polymorphismsGC/CCAIH groupHepatitis severityMIF promoterSteroid resistanceMIF genotypeSerum ALTSymptomatic presentationGG patientsHigher ALTClinical parametersMIF polymorphisms