Targeting prostate cancer with Clostridium perfringens enterotoxin functionalized nanoparticles co-encapsulating imaging cargo enhances magnetic resonance imaging specificity
Martin DT, Lee JS, Liu Q, Galiana G, Sprenkle PC, Humphrey PA, Petrylak DP, Weinreb JC, Schulam PG, Weiss RM, Fahmy TM. Targeting prostate cancer with Clostridium perfringens enterotoxin functionalized nanoparticles co-encapsulating imaging cargo enhances magnetic resonance imaging specificity. Nanomedicine Nanotechnology Biology And Medicine 2021, 40: 102477. PMID: 34740868, DOI: 10.1016/j.nano.2021.102477.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnterotoxinsHumansMagnetic Resonance ImagingMaleMiceNanoparticlesProstatic NeoplasmsConceptsFunctionalized nanoparticlesProstate cancerTumor specificityNanoparticlesHuman prostate cancer biopsiesTumor-bearing mouse modelClaudin-3Average diameterLiver signal intensityProstate cancer biopsiesKey imaging toolContrast-enhanced MRIImaging specificityClostridium perfringens enterotoxinPotential clinical applicabilityDetection toolsMouse modelTumor localizationCancer biopsiesCancer specificityCldn-3Perfringens enterotoxinClinical applicabilityHigh expressionHigh grade