2019
Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target
Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM. Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target. Molecular Cancer Therapeutics 2019, 18: molcanther.1079.2017. PMID: 30381445, PMCID: PMC6363894, DOI: 10.1158/1535-7163.mct-17-1079.Peer-Reviewed Original ResearchConceptsBladder cancer cell linesBladder tumorsBladder cancerCancer cell linesHigh-grade bladder cancer cell linesCancer xenograft mouse modelBladder cancer growthAggressive bladder cancerPotential therapeutic targetHuman bladder tumorsXenograft mouse modelBladder cancer progressionCell linesBladder tumor cellsCurative potentialOptimal treatmentTumor gradePatient outcomesReduced cell migrationTumor volumeTumor categoryMouse modelTherapeutic targetTumor aggressivenessCancer growth
2015
Blocking Glycoprotein‐130 Pathway Decreases Bladder Cancer Growth
Martin D, Steinbach J, Saltzman W, Weiss R. Blocking Glycoprotein‐130 Pathway Decreases Bladder Cancer Growth. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.889.11.Peer-Reviewed Original ResearchBacillus Calmette-GuerinExpression of gp130Bladder cancer cellsBladder cancerCancer specimensNon-muscle invasive bladder cancerCancer cellsEffective adjuvant agentInvasive bladder cancerWeeks of treatmentBladder cancer tissue microarrayBladder cancer growthComprehensive cancer centerBladder cancer specimensCancer tissue microarrayHuman bladder cancerAdjuvant agentBladder tumorsCancer CenterCytokeratin 20Signal transduction pathwaysCalmette-GuerinTumor gradeTissue microarrayCarcinoma markers