A novel polymer-coated nanoparticle (NP) for urothelium penetration and drug delivery.
Hoimes C, Martin D, Kaimakliotis H, Cheng C, Kelly W, Tew G, Wheeler M, Weiss R, Saltzman W. A novel polymer-coated nanoparticle (NP) for urothelium penetration and drug delivery. Journal Of Clinical Oncology 2013, 31: e15543-e15543. DOI: 10.1200/jco.2013.31.15_suppl.e15543.Peer-Reviewed Original ResearchBladder cancerUM-UC-3Human ureterProgression of BCNon-invasive bladder cancerInhibition of invasionHDAC inhibitor belinostatFlank xenograftsTumor sizeDisease progressionTumor regressionUrothelial barrierTumor volumeIntravesical drug deliveryMouse bladderBC cellsHDAC inhibitionMurine bladderCell cytotoxicityT24 lineFACS analysisSimilar IC50Three daysFinal treatmentUreter