Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi
Salerno-Goncalves R, Kayastha D, Fasano A, Levine MM, Sztein MB. Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi. PLOS Neglected Tropical Diseases 2019, 13: e0007650. PMID: 31412039, PMCID: PMC6709971, DOI: 10.1371/journal.pntd.0007650.Peer-Reviewed Original ResearchConceptsSalmonella enterica serovar TyphiParatyphi AEnterica serovar TyphiIL-8Paratyphi BEpithelial cellsSerovar TyphiCytokines/chemokinesPro-inflammatory cytokinesDifferential immune responsesLife-threatening illnessHuman intestinal mucosaSimilar clinical symptomsPolymorphonuclear leukocyte migrationInnate cellsClinical symptomsEnteric feverIL-1βIL-6Three-dimensional organotypic modelImmune responseIntestinal mucosaDistinct epidemiologyLeukocyte migrationSecretion pattern