2021
Effects of Reduced Nicotine Content Cigarettes on Fractional Exhaled Nitric Oxide and Self-Reported Respiratory Health Outcomes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage
Oliver A, DeSarno M, Irvin C, Kaminsky D, Tidey J, Sigmon S, Heil S, Gaalema D, Lee D, Bunn J, Davis D, Streck J, Gallagher T, Higgins S. Effects of Reduced Nicotine Content Cigarettes on Fractional Exhaled Nitric Oxide and Self-Reported Respiratory Health Outcomes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage. Nicotine & Tobacco Research 2021, 24: 135-140. PMID: 34255068, PMCID: PMC8826384, DOI: 10.1093/ntr/ntab145.Peer-Reviewed Original ResearchConceptsOpioid use disorderRespiratory health questionnaireFeNO levelsAffective disordersSocioeconomic disadvantageContent cigarettesEpithelial healthHealth outcomesSignificant dose-related changesReduced nicotine content cigarettesNicotine contentNitric oxideAssociations of FeNOHealthy respiratory systemHigher FeNO levelsSmoking-related decreaseSmoking-related reductionRespiratory health outcomesDose-related changesCigarette nicotine contentNicotine content cigarettesAdverse health outcomesAdult daily smokersCombustible tobacco useFeNO changes
2019
Examining Age as a Potential Moderator of Response to Reduced Nicotine Content Cigarettes in Vulnerable Populations
Davis D, Parker M, Villanti A, Streck J, Priest J, Tidey J, Gaalema D, Sigmon S, Heil S, Higgins S. Examining Age as a Potential Moderator of Response to Reduced Nicotine Content Cigarettes in Vulnerable Populations. Nicotine & Tobacco Research 2019, 21: s49-s55. PMID: 31867655, PMCID: PMC6939764, DOI: 10.1093/ntr/ntz134.Peer-Reviewed Original ResearchConceptsReduced nicotine content cigarettesNicotine content cigarettesYoung adult smokersNicotine reduction policyContent cigarettesCraving/withdrawalAdult smokersCigarette smokingSmoking topographyYoung adultsAge groupsNicotine contentSubjective effectsSmoking-related health consequencesOlder adultsAddiction potentialOlder adult smokersHigh smoking prevalenceComorbid psychiatric conditionsOlder age groupsOverall population healthEffect of ageCigarette smokersSmoking prevalenceAcute effectsExamining effects of unit price on preference for reduced nicotine content cigarettes and smoking rate
Davis D, DeSarno M, Bergeria C, Streck J, Tidey J, Sigmon S, Heil S, Gaalema D, Stitzer M, Higgins S. Examining effects of unit price on preference for reduced nicotine content cigarettes and smoking rate. Preventive Medicine 2019, 128: 105823. PMID: 31470023, PMCID: PMC6879848, DOI: 10.1016/j.ypmed.2019.105823.Peer-Reviewed Original ResearchConceptsNicotine content cigarettesReduced nicotine content cigarettesContent cigarettesSmoking ratesVulnerable populationsLower smoking ratesNormal nicotine content cigarettesNicotine contentCigarette preferenceSmoking reductionDaily smokersDoseMultisite studyCondition 2CigarettesCondition 1Tobacco regulationPresent studyBinomial testSmokersSmokingPopulationNicotineResponse to Reduced Nicotine Content in Vulnerable Populations: Effect of Menthol Status
Davis D, Miller M, Streck J, Bergeria C, Sigmon S, Tidey J, Heil S, Gaalema D, Villanti A, Stitzer M, Priest J, Bunn J, Skelly J, Diaz V, Arger C, Higgins S. Response to Reduced Nicotine Content in Vulnerable Populations: Effect of Menthol Status. Tobacco Regulatory Science 2019, 5: 135-142. PMID: 31890749, PMCID: PMC6936762, DOI: 10.18001/trs.5.2.5.Peer-Reviewed Original ResearchWithdrawal/cravingMenthol statusMenthol smokersNicotine doseDouble-blind studyComorbid mental illnessNicotine content cigarettesPotential beneficial effectsSubstance use disordersNicotine contentSmoking topographyCompensatory smokingContent cigarettesRNC cigarettesUse disordersSmokersHigh dosesMental illnessResearch cigarettesSmokingBeneficial effectsCigarettesAddiction potentialSocioeconomic disadvantageVulnerable populations
2018
Reduced Nicotine Content Cigarettes and Cannabis Use in Vulnerable Populations
Parker M, Streck J, Bergeria C, Bunn J, Gaalema D, Davis D, Barrows A, Sigmon S, Tidey J, Heil S, Higgins S. Reduced Nicotine Content Cigarettes and Cannabis Use in Vulnerable Populations. Tobacco Regulatory Science 2018, 4: 84-91. PMID: 30417034, PMCID: PMC6219758, DOI: 10.18001/trs.4.5.8.Peer-Reviewed Original ResearchNicotine content cigarettesCarbon monoxide boostSmoking topographyContent cigarettesCannabis usersCannabis useConcurrent choice testingCo-morbid conditionsVulnerable populationsConcurrent affective disorderMore rapid declineRespiratory tract sensationsSymptom durationRecent cannabis useSmoking satisfactionOpioid dependenceNicotine dosesTobacco withdrawalNicotine doseAdult smokersAcute responseAffective disordersSociodemographic characteristicsSecondary analysisModerate response
2017
A review of the effects of very low nicotine content cigarettes on behavioral and cognitive performance
Keith D, Kurti A, Davis D, Zvorsky I, Higgins S. A review of the effects of very low nicotine content cigarettes on behavioral and cognitive performance. Preventive Medicine 2017, 104: 100-116. PMID: 28647546, PMCID: PMC5831363, DOI: 10.1016/j.ypmed.2017.06.016.Peer-Reviewed Original Research
2016
Response to varying the nicotine content of cigarettes in vulnerable populations: an initial experimental examination of acute effects
Higgins S, Heil S, Sigmon S, Tidey J, Gaalema D, Stitzer M, Durand H, Bunn J, Priest J, Arger C, Miller M, Bergeria C, Davis D, Streck J, Zvorsky I, Redner R, Vandrey R, Pacek L. Response to varying the nicotine content of cigarettes in vulnerable populations: an initial experimental examination of acute effects. Psychopharmacology 2016, 234: 89-98. PMID: 27714427, PMCID: PMC5203959, DOI: 10.1007/s00213-016-4438-z.Peer-Reviewed Original ResearchConceptsNicotine withdrawalSmoking topographyVulnerable populationsLow nicotine content cigarettesConcurrent choice testingNicotine contentDouble-blind conditionsOpioid-dependent individualsNicotine content cigarettesResultsNo significant differencesDaily cigarette smokersBrief smoking abstinenceRationaleThe purposeCigarette smokersCompensatory smokingSmoking abstinenceReproductive ageAcute effectsContent cigarettesUntoward effectsAffective disordersLow dosesResearch cigarettesDisadvantaged womenDependence potential