2024
Peer Comparison or Guideline-Based Feedback and Postsurgery Opioid Prescriptions
Wagner Z, Kirkegaard A, Mariano L, Doctor J, Yan X, Persell S, Goldstein N, Fox C, Brummett C, Romanelli R, Bouskill K, Martinez M, Zanocco K, Meeker D, Mudiganti S, Waljee J, Watkins K. Peer Comparison or Guideline-Based Feedback and Postsurgery Opioid Prescriptions. JAMA Health Forum 2024, 5: e240077. PMID: 38488780, PMCID: PMC10943416, DOI: 10.1001/jamahealthforum.2024.0077.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidFeedbackFemaleHumansOpioid-Related DisordersPractice Patterns, Physicians'PrescriptionsConceptsCluster randomized clinical trialPeer comparison interventionOpioid prescribingEmail feedbackGuideline interventionComparison interventionIntervention periodHealth care delivery systemRandomized clinical trialsOpioid prescriptionsCare delivery systemPeer comparisonExcessive opioid prescribingSocial norm-based interventionsControl groupIntervention monthsMain OutcomesQuantity of opioidsClinical trialsDischarged patientsPeer surgeonsPrescribingOpioid misuseInterventionSurgical specialties
2022
A Qualitative Description of Clinician Free-Text Rationales Entered within Accountable Justification Interventions
Brown T, Zelch B, Lee J, Doctor J, Linder J, Sullivan M, Goldstein N, Rowe T, Meeker D, Knight T, Friedberg M, Persell S. A Qualitative Description of Clinician Free-Text Rationales Entered within Accountable Justification Interventions. Applied Clinical Informatics 2022, 13: 820-827. PMID: 36070799, PMCID: PMC9451951, DOI: 10.1055/s-0042-1756366.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalgesics, OpioidDecision Support Systems, ClinicalHumansPhysiciansPractice Patterns, Physicians'Social ResponsibilityConceptsClinical content areasClinical appropriatenessClinical decision support alertsPrimary care physiciansDecision support alertsAppropriate clinical decisionsUnique cliniciansOpioid prescribingCare physiciansClinical detailsAccountable justificationCDS alertsPilot interventionClinical decisionClinical casesCliniciansParticular diagnosisOlder adultsInterventionPhysiciansDelphi techniquePolypharmacyPrescribingPatientsSymptomsThe protocol of improving safe antibiotic prescribing in telehealth: A randomized trial
McCabe B, Linder J, Doctor J, Friedberg M, Fox C, Goldstein N, Knight T, Kaiser K, Tibbels J, Haenchen S, Persell S, Warberg R, Meeker D. The protocol of improving safe antibiotic prescribing in telehealth: A randomized trial. Contemporary Clinical Trials 2022, 119: 106834. PMID: 35724841, DOI: 10.1016/j.cct.2022.106834.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsElectronic Health RecordsHumansInappropriate PrescribingPractice Patterns, Physicians'Randomized Controlled Trials as TopicRespiratory Tract InfectionsTelemedicineConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesAntibiotic prescribingPrescribing ratesRandomized quality improvement trialAntibiotic stewardship interventionsInappropriate antibiotic prescriptionsUrgent care visitsPrevious randomized trialsPrimary care clinicsQuality improvement trialEffective antibiotic useElectronic health recordsARI visitsInappropriate prescribingAntibiotic prescriptionsCare visitsSecondary outcomesPrimary outcomeRespiratory infectionsCare clinicsRandomized trialsStewardship interventionsAntibiotic use
2021
The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety trial 2 (AESOPS-2): Availability of opioid harm
Kelley M, Persell S, Linder J, Friedberg M, Meeker D, Fox C, Goldstein N, Knight T, Zein D, Sullivan M, Doctor J. The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety trial 2 (AESOPS-2): Availability of opioid harm. Contemporary Clinical Trials 2021, 112: 106650. PMID: 34896295, PMCID: PMC8869359, DOI: 10.1016/j.cct.2021.106650.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidDrug OverdoseHumansMulticenter Studies as TopicOpioid-Related DisordersPractice Patterns, Physicians'Psychology, SocialRandomized Controlled Trials as TopicUnited StatesConceptsProportion of patientsOpioid-related overdosesOpioid prescribingOpioid-related harmsOpioid use disorderTrial 2Mixed effects regression modelsHarmful patient outcomesDaily MMEMorphine equivalentsPatient overdoseUsual careOpioid usePrimary outcomePrescriber awarenessOpioid harmsPrescribing SafetyPrevention recommendationsIntervention groupPatient outcomesOpioid overdosesUse disordersTreat differencesDisease controlAdditional outcomesThe protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges
Kelley M, Persell S, Linder J, Friedberg M, Meeker D, Fox C, Goldstein N, Knight T, Zein D, Rowe T, Sullivan M, Doctor J. The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges. Contemporary Clinical Trials 2021, 103: 106329. PMID: 33636344, PMCID: PMC8089040, DOI: 10.1016/j.cct.2021.106329.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidElectronic Health RecordsHumansOpioid-Related DisordersPractice Patterns, Physicians'Psychology, SocialRandomized Controlled Trials as TopicConceptsEHR-based interventionsElectronic health recordsPrimary careLong-term opioid useHigh-risk prescriptionsProportion of patientsPrimary care clinicsTrial 1Mixed-effects regression modelsPersistence of effectsDaily MMEMorphine equivalentsNoncancer painLack of evidenceOpioid prescribingOpioid useSecondary outcomesDaily dosePrimary outcomeCare clinicsIntervention armPrescribing SafetyClinical guidelinesControl armIntervention period
2020
Details matter: predicting when nudging clinicians will succeed or fail
Fox C, Doctor J, Goldstein N, Meeker D, Persell S, Linder J. Details matter: predicting when nudging clinicians will succeed or fail. The BMJ 2020, 370: m3256. PMID: 32933926, DOI: 10.1136/bmj.m3256.Peer-Reviewed Original ResearchBehavior ControlChoice BehaviorDecision MakingHumansPractice Patterns, Physicians'Quality of Health Care
2019
A Multifaceted Intervention Improves Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings
Yadav K, Meeker D, Mistry R, Doctor J, Fleming‐Dutra K, Fleischman R, Gaona S, Stahmer A, May L. A Multifaceted Intervention Improves Prescribing for Acute Respiratory Infection for Adults and Children in Emergency Department and Urgent Care Settings. Academic Emergency Medicine 2019, 26: 719-731. PMID: 31215721, PMCID: PMC8146207, DOI: 10.1111/acem.13690.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsEmergency departmentARI visitsRespiratory infectionsStewardship interventionsUrgent care center visitsViral acute respiratory infectionsHierarchical mixed-effects logistic regression modelsCluster-randomized clinical trialHealth systemAntibiotic stewardship interventionsUrgent care settingsOutpatient antibiotic prescriptionsPediatric emergency departmentMixed effects logistic regression modelsAcademic health systemLogistic regression modelsInappropriate prescribingAntibiotic prescribingAntibiotic prescriptionsInappropriate prescriptionsInfluenza seasonAntibiotic stewardshipClinical trialsOdds ratio
2018
Behavioral Economics Interventions to Improve Outpatient Antibiotic Prescribing for Acute Respiratory Infections: a Cost-Effectiveness Analysis
Gong C, Zangwill K, Hay J, Meeker D, Doctor J. Behavioral Economics Interventions to Improve Outpatient Antibiotic Prescribing for Acute Respiratory Infections: a Cost-Effectiveness Analysis. Journal Of General Internal Medicine 2018, 34: 846-854. PMID: 29740788, PMCID: PMC6544688, DOI: 10.1007/s11606-018-4467-x.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsQuality-adjusted life yearsInappropriate antibiotic prescriptionsAntibiotic prescriptionsBehavioral economic interventionsElectronic health recordsAntibiotic prescribingRespiratory infectionsProvider educationAccountable justificationSymptoms of ARIComputerized clinical decision supportIncremental cost-effectiveness ratioOutpatient antibiotic prescribingInappropriate antibiotic prescribingAssociated adverse eventsHealthcare resource utilizationTotal quality-adjusted life yearsHigher quality-adjusted life yearsCost-effectiveness ratioCDC surveillance dataPatients' electronic health recordsCost-effectiveness analysisUS societal perspectiveAdverse events
2017
Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions
Linder J, Meeker D, Fox C, Friedberg M, Persell S, Goldstein N, Doctor J. Effects of Behavioral Interventions on Inappropriate Antibiotic Prescribing in Primary Care 12 Months After Stopping Interventions. JAMA 2017, 318: 1391-1392. PMID: 29049577, PMCID: PMC5818848, DOI: 10.1001/jama.2017.11152.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsElectronic Health RecordsFollow-Up StudiesHumansInappropriate PrescribingLogistic ModelsPeer GroupPractice Patterns, Physicians'Primary Health CareRespiratory Tract Infections
2016
Behavioral interventions to reduce inappropriate antibiotic prescribing: a randomized pilot trial
Persell S, Doctor J, Friedberg M, Meeker D, Friesema E, Cooper A, Haryani A, Gregory D, Fox C, Goldstein N, Linder J. Behavioral interventions to reduce inappropriate antibiotic prescribing: a randomized pilot trial. BMC Infectious Diseases 2016, 16: 373. PMID: 27495917, PMCID: PMC4975897, DOI: 10.1186/s12879-016-1715-8.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnti-Bacterial AgentsBehaviorDecision MakingDecision Support Systems, ClinicalEducation, Medical, ContinuingFemaleHumansInappropriate PrescribingInterprofessional RelationsMaleMiddle AgedPharyngitisPhysicians, Primary CarePilot ProjectsPractice Patterns, Physicians'PrescriptionsRespiratory Tract InfectionsSinusitisConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribingRespiratory infectionsDiagnosis/symptomsARI diagnosesBehavioral interventionsAntibiotic prescribing ratesRandomized pilot trialPre-intervention yearInappropriate prescribingPrescribing ratesCare cliniciansAccountable justificationPilot trialPrescribingIntervention yearPharyngitisInfectionFloor effectsSymptomsDiagnosisPeer comparisonInterventionHawthorne effectCharacterizing treatment pathways at scale using the OHDSI network
Hripcsak G, Ryan P, Duke J, Shah N, Park R, Huser V, Suchard M, Schuemie M, DeFalco F, Perotte A, Banda J, Reich C, Schilling L, Matheny M, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 7329-7336. PMID: 27274072, PMCID: PMC4941483, DOI: 10.1073/pnas.1510502113.Peer-Reviewed Original ResearchConceptsAdministrative claims dataTreatment pathwaysClaims dataType 2 diabetes mellitusFirst-line medicationElectronic health record dataClinical trial resultsObservational researchHealth record dataElectronic health recordsDiabetes mellitusHypertension patientsDepression patientsConsistent therapyObservational studyOHDSI networkObservational Health Data SciencesPatientsTrial resultsClinical hypothesisHealth recordsRecord dataSignificant heterogeneityHealth Data SciencesHypertensionCognitive reflection and antibiotic prescribing for acute respiratory infections
Pineros D, Doctor J, Friedberg M, Meeker D, Linder J. Cognitive reflection and antibiotic prescribing for acute respiratory infections. Family Practice 2016, 33: 309-311. PMID: 27006411, PMCID: PMC4931815, DOI: 10.1093/fampra/cmw015.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsAntibiotic prescribing ratesAntibiotic prescribingPrescribing ratesRespiratory infectionsCommon clinical decisionsPrescription of antibioticsElectronic health record dataPrimary care practicesHealth record dataCare practicesClinicians' tendenciesClinical decisionPrescribingRecord dataCliniciansInfectionAntibioticsHigher scoresScoresPsychological testsCareEffect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial
Meeker D, Linder J, Fox C, Friedberg M, Persell S, Goldstein N, Knight T, Hay J, Doctor J. Effect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial. JAMA 2016, 315: 562-570. PMID: 26864410, PMCID: PMC6689234, DOI: 10.1001/jama.2016.0275.Peer-Reviewed Original ResearchConceptsAcute respiratory tract infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesRespiratory tract infectionsPrimary care practicesAntibiotic prescribingPrescribing ratesTract infectionsAccountable justificationCare practicesBehavioral interventionsElectronic health recordsClinical trialsAntibiotic prescribing guidelinesElectronic order setsPatients' electronic health recordsAdult patientsPrescribing guidelinesAmbulatory visitsMonth 18Concomitant infectionNonantibiotic treatmentIntervention periodMonths preinterventionMAIN OUTCOME
2014
Patient Satisfaction as a Quality Metric Promotes Bad Medicine—Reply
Meeker D, Friedberg M, Linder J. Patient Satisfaction as a Quality Metric Promotes Bad Medicine—Reply. JAMA Internal Medicine 2014, 174: 1419-1419. PMID: 25090189, PMCID: PMC4648558, DOI: 10.1001/jamainternmed.2014.1594.Peer-Reviewed Original ResearchNudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trial
Meeker D, Knight T, Friedberg M, Linder J, Goldstein N, Fox C, Rothfeld A, Diaz G, Doctor J. Nudging Guideline-Concordant Antibiotic Prescribing: A Randomized Clinical Trial. JAMA Internal Medicine 2014, 174: 425-431. PMID: 24474434, PMCID: PMC4648560, DOI: 10.1001/jamainternmed.2013.14191.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsDrug PrescriptionsGuideline AdherenceHumansInappropriate PrescribingInfectionsMaleMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Primary Health CareConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesPrescribing ratesAntibiotic prescribingClinical trialsIntervention periodOutpatient primary care clinicsInappropriate prescribing ratePrimary care clinicsAppropriate antibiotic prescriptionRandomized clinical trialsExamination roomLow-cost interventionStandard practice controlsQuality improvement effortsARI diagnosesARI visitsAntibiotic prescriptionsPatient ageRespiratory infectionsCare clinicsInsurance statusMAIN OUTCOMEClinical practice