2024
Drivers of Variation in Opioid Prescribing after Common Surgical Procedures in a Large Multihospital Healthcare System
Zanocco K, Romanelli R, Meeker D, Mariano L, Shenoy R, Wagner Z, Kirkegaard A, Mudiganti S, Martinez M, Watkins K. Drivers of Variation in Opioid Prescribing after Common Surgical Procedures in a Large Multihospital Healthcare System. Journal Of The American College Of Surgeons 2024, 239: 242-252. PMID: 38690834, PMCID: PMC11321601, DOI: 10.1097/xcs.0000000000001095.Peer-Reviewed Original ResearchElectronic health recordsMultihospital healthcare systemOpioid prescribingHealthcare systemNon-Hispanic black raceMorphine milligram equivalentsPrimary care providersReducing postoperative opioid prescribingOpioid prescribing practicesInfluence pain levelsRandom-effects modelCare providersPatient safetyHealth recordsProvider levelInsurance statusMisuse of prescription opioidsPostoperative opioid prescribingPatient racePrescribing behaviorPrescribing variationGuideline recommendationsPrescribing practicesTargeted prescribingMedicare insurance
2023
Integrating REDCap patient-reported outcomes with the HealtheIntent population health platform: proof of concept
Espinoza J, Tut M, Shah P, Kingsbury P, Nagaraj G, Meeker D, Bahroos N. Integrating REDCap patient-reported outcomes with the HealtheIntent population health platform: proof of concept. JAMIA Open 2023, 6: ooad074. PMID: 37649989, PMCID: PMC10463552, DOI: 10.1093/jamiaopen/ooad074.Peer-Reviewed Original Research
2022
The protocol of improving safe antibiotic prescribing in telehealth: A randomized trial
McCabe B, Linder J, Doctor J, Friedberg M, Fox C, Goldstein N, Knight T, Kaiser K, Tibbels J, Haenchen S, Persell S, Warberg R, Meeker D. The protocol of improving safe antibiotic prescribing in telehealth: A randomized trial. Contemporary Clinical Trials 2022, 119: 106834. PMID: 35724841, DOI: 10.1016/j.cct.2022.106834.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesAntibiotic prescribingPrescribing ratesRandomized quality improvement trialAntibiotic stewardship interventionsInappropriate antibiotic prescriptionsUrgent care visitsPrevious randomized trialsPrimary care clinicsQuality improvement trialEffective antibiotic useElectronic health recordsARI visitsInappropriate prescribingAntibiotic prescriptionsCare visitsSecondary outcomesPrimary outcomeRespiratory infectionsCare clinicsRandomized trialsStewardship interventionsAntibiotic useDevelopment of High-Risk Geriatric Polypharmacy Electronic Clinical Quality Measures and a Pilot Test of EHR Nudges Based on These Measures
Persell S, Brown T, Doctor J, Fox C, Goldstein N, Handler S, Hanlon J, Lee J, Linder J, Meeker D, Rowe T, Sullivan M, Friedberg M. Development of High-Risk Geriatric Polypharmacy Electronic Clinical Quality Measures and a Pilot Test of EHR Nudges Based on These Measures. Journal Of General Internal Medicine 2022, 37: 2777-2785. PMID: 34993860, PMCID: PMC9411452, DOI: 10.1007/s11606-021-07296-1.Peer-Reviewed Original ResearchConceptsHigh-risk criteriaNon-dihydropyridine calcium channel blockersMore high-risk criteriaSingle large health systemThree-arm pilotChronic kidney diseaseHigh-risk medicationsCalcium channel blockersLarge health systemDrug-drug interactionsClinical quality measuresElectronic health recordsEHR alertMain MeasuresRatesMore medicationsPatients 65Older patientsHeart failureKey ResultsAmongKidney diseaseNovel electronic health recordPolypharmacyChannel blockersFall historyPatients
2021
Design of Behavioral Economic Applications to Geriatrics Leveraging Electronic Health Records (BEAGLE): A pragmatic cluster randomized controlled trial
Brown T, Rowe T, Lee J, Petito L, Chmiel R, Ciolino J, Doctor J, Fox C, Goldstein N, Kaiser D, Linder J, Meeker D, Peprah Y, Persell S. Design of Behavioral Economic Applications to Geriatrics Leveraging Electronic Health Records (BEAGLE): A pragmatic cluster randomized controlled trial. Contemporary Clinical Trials 2021, 112: 106649. PMID: 34896294, PMCID: PMC8724916, DOI: 10.1016/j.cct.2021.106649.Peer-Reviewed Original ResearchConceptsPrimary care clinicsProstate-specific antigenCo-primary outcomesElectronic health recordsCare clinicsOlder adultsClinician educationParallel armsPragmatic cluster-randomized trialNon-specific reasonsOvertreatment of diabetesClinical decision support interventionHealth recordsPrimary care cliniciansChoosing Wisely campaignLarge regional health systemCluster-randomized trialDecision support interventionsPragmatic clusterRegional health systemOlder patientsStudy armsCare cliniciansDiabetes measuresUrine testingThe protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges
Kelley M, Persell S, Linder J, Friedberg M, Meeker D, Fox C, Goldstein N, Knight T, Zein D, Rowe T, Sullivan M, Doctor J. The protocol of the Application of Economics & Social psychology to improve Opioid Prescribing Safety Trial 1 (AESOPS-1): Electronic health record nudges. Contemporary Clinical Trials 2021, 103: 106329. PMID: 33636344, PMCID: PMC8089040, DOI: 10.1016/j.cct.2021.106329.Peer-Reviewed Original ResearchConceptsEHR-based interventionsElectronic health recordsPrimary careLong-term opioid useHigh-risk prescriptionsProportion of patientsPrimary care clinicsTrial 1Mixed-effects regression modelsPersistence of effectsDaily MMEMorphine equivalentsNoncancer painLack of evidenceOpioid prescribingOpioid useSecondary outcomesDaily dosePrimary outcomeCare clinicsIntervention armPrescribing SafetyClinical guidelinesControl armIntervention period
2018
Behavioral Economics Interventions to Improve Outpatient Antibiotic Prescribing for Acute Respiratory Infections: a Cost-Effectiveness Analysis
Gong C, Zangwill K, Hay J, Meeker D, Doctor J. Behavioral Economics Interventions to Improve Outpatient Antibiotic Prescribing for Acute Respiratory Infections: a Cost-Effectiveness Analysis. Journal Of General Internal Medicine 2018, 34: 846-854. PMID: 29740788, PMCID: PMC6544688, DOI: 10.1007/s11606-018-4467-x.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsQuality-adjusted life yearsInappropriate antibiotic prescriptionsAntibiotic prescriptionsBehavioral economic interventionsElectronic health recordsAntibiotic prescribingRespiratory infectionsProvider educationAccountable justificationSymptoms of ARIComputerized clinical decision supportIncremental cost-effectiveness ratioOutpatient antibiotic prescribingInappropriate antibiotic prescribingAssociated adverse eventsHealthcare resource utilizationTotal quality-adjusted life yearsHigher quality-adjusted life yearsCost-effectiveness ratioCDC surveillance dataPatients' electronic health recordsCost-effectiveness analysisUS societal perspectiveAdverse events
2016
Characterizing treatment pathways at scale using the OHDSI network
Hripcsak G, Ryan P, Duke J, Shah N, Park R, Huser V, Suchard M, Schuemie M, DeFalco F, Perotte A, Banda J, Reich C, Schilling L, Matheny M, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 7329-7336. PMID: 27274072, PMCID: PMC4941483, DOI: 10.1073/pnas.1510502113.Peer-Reviewed Original ResearchConceptsAdministrative claims dataTreatment pathwaysClaims dataType 2 diabetes mellitusFirst-line medicationElectronic health record dataClinical trial resultsObservational researchHealth record dataElectronic health recordsDiabetes mellitusHypertension patientsDepression patientsConsistent therapyObservational studyOHDSI networkObservational Health Data SciencesPatientsTrial resultsClinical hypothesisHealth recordsRecord dataSignificant heterogeneityHealth Data SciencesHypertensionEffect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial
Meeker D, Linder J, Fox C, Friedberg M, Persell S, Goldstein N, Knight T, Hay J, Doctor J. Effect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial. JAMA 2016, 315: 562-570. PMID: 26864410, PMCID: PMC6689234, DOI: 10.1001/jama.2016.0275.Peer-Reviewed Original ResearchConceptsAcute respiratory tract infectionsInappropriate antibiotic prescribingAntibiotic prescribing ratesRespiratory tract infectionsPrimary care practicesAntibiotic prescribingPrescribing ratesTract infectionsAccountable justificationCare practicesBehavioral interventionsElectronic health recordsClinical trialsAntibiotic prescribing guidelinesElectronic order setsPatients' electronic health recordsAdult patientsPrescribing guidelinesAmbulatory visitsMonth 18Concomitant infectionNonantibiotic treatmentIntervention periodMonths preinterventionMAIN OUTCOME
2015
Evaluating the feasibility and utility of translating Choosing Wisely recommendations into e-Measures
Shetty K, Meeker D, Schneider E, Hussey P, Damberg C. Evaluating the feasibility and utility of translating Choosing Wisely recommendations into e-Measures. Healthcare 2015, 3: 24-37. PMID: 26179586, DOI: 10.1016/j.hjdsi.2014.12.002.Peer-Reviewed Original Research
2014
Nudging Physician Prescription Decisions by Partitioning the Order Set: Results of a Vignette-Based Study
Tannenbaum D, Doctor J, Persell S, Friedberg M, Meeker D, Friesema E, Goldstein N, Linder J, Fox C. Nudging Physician Prescription Decisions by Partitioning the Order Set: Results of a Vignette-Based Study. Journal Of General Internal Medicine 2014, 30: 298-304. PMID: 25394536, PMCID: PMC4351289, DOI: 10.1007/s11606-014-3051-2.Peer-Reviewed Original ResearchConceptsEHR order setsPrimary care providersElectronic health recordsNarrow-spectrum antibioticsOrder setsTreatment menuTreatment choiceCare providersMain MeasuresThe main outcomeAggressive treatment optionsAcute respiratory infectionsPhysician prescription decisionsBroad-spectrum antibioticsRespiratory infectionsPrescribing practicesCounter medicationsTreatment optionsPrescription decisionsMAIN OUTCOMEPatient careTypical signsBackgroundHealthcare professionalsPrescription drugsProvider decisionsAggressive optionsUnderstanding data requirements of retrospective studies
Shenvi E, Meeker D, Boxwala A. Understanding data requirements of retrospective studies. International Journal Of Medical Informatics 2014, 84: 76-84. PMID: 25453276, PMCID: PMC6626658, DOI: 10.1016/j.ijmedinf.2014.10.004.Peer-Reviewed Original Research
2013
Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01] - study protocol and baseline practice and provider characteristics
Persell S, Friedberg M, Meeker D, Linder J, Fox C, Goldstein N, Shah P, Knight T, Doctor J. Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01] - study protocol and baseline practice and provider characteristics. BMC Infectious Diseases 2013, 13: 290. PMID: 23806017, PMCID: PMC3701464, DOI: 10.1186/1471-2334-13-290.Peer-Reviewed Original ResearchConceptsAcute respiratory infectionsInappropriate antibiotic prescribingAntibiotic prescribingInappropriate prescribingRespiratory infectionsComputerized clinical decision supportAntibiotic prescribing ratesTrial study protocolInappropriate antibiotic useAdverse drug eventsCost of careUnit of randomizationPatients' electronic health recordsElectronic health recordsPersistence of effectsARI diagnosesNonbacterial infectionsAntibiotic prescriptionsSecondary outcomesClinical decision supportPrescribing ratesPrimary outcomeBehavioral economic strategiesGuideline recommendationsYear follow