Upregulation of thymidine phosphorylase (TP) by radiation (XRT): Phase II study of capecitabine (CAP) with XRT in pts with locally advanced (LA) pancreatic cancer
Roy S, Russo S, Black G, Eloubeidi M, Steg A, Zelterman D, Johnson M, Diasio R, Saif M. Upregulation of thymidine phosphorylase (TP) by radiation (XRT): Phase II study of capecitabine (CAP) with XRT in pts with locally advanced (LA) pancreatic cancer. Journal Of Clinical Oncology 2006, 24: 14001-14001. DOI: 10.1200/jco.2006.24.18_suppl.14001.Peer-Reviewed Original ResearchPhase II studyLA pancreatic cancerEfficacy of capecitabinePancreatic cancerII studyTNF-alphaThymidine phosphorylaseGI bleedingDose reductionSix-month survival ratesTP/DPD ratioTNF-alpha mRNA levelsPhase IActivity of capecitabineAdvanced pancreatic cancerGrade 1 anemiaGrade 1 thrombocytopeniaNausea/vomitingPts underwent surgeryEffect of XRTConcurrent XRTStable diseaseUnderwent surgeryMedian survivalPartial response