2004
Neurotrophic effects of BDNF on embryonic gonadotropin‐releasing hormone (GnRH) neurons
Cronin AS, Horan TL, Spergel DJ, Brooks AN, Hastings MH, Ebling FJ. Neurotrophic effects of BDNF on embryonic gonadotropin‐releasing hormone (GnRH) neurons. European Journal Of Neuroscience 2004, 20: 338-344. PMID: 15233743, DOI: 10.1111/j.1460-9568.2004.03490.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain-Derived Neurotrophic FactorCell CountCells, CulturedCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianGonadotropin-Releasing HormoneGreen Fluorescent ProteinsImmunoenzyme TechniquesImmunohistochemistryLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicMitogen-Activated Protein KinasesNeuritesNeuronsOligodeoxyribonucleotides, AntisensePotassium ChlorideReceptor, trkBConceptsBrain-derived neurotrophic factorGnRH cellsNeurotrophic factorMedian eminenceGonadotropin-releasing hormone (GnRH) neuronsNeurite outgrowthGnRH secretory systemGnRH-immunoreactive cellsGonadotropin-releasing hormoneDose-dependent increaseResponse element-binding proteinPhosphorylation of ERKHormone neuronsBDNF treatmentGnRH neuronsNeurotrophic effectsPreoptic areaNeurons migrateReproductive axisElement-binding proteinOlfactory placodeOlfactory tissuePrimary culturesERK pathwayGnRH
1994
Glutamate Modulates [Ca2+]i and Gonadotropin-Releasing Hormone Secretion in Immortalized Hypothalamic GT1-7 Neurons
Spergel D, Krsmanovic L, Stojilkovic S, Catt K. Glutamate Modulates [Ca2+]i and Gonadotropin-Releasing Hormone Secretion in Immortalized Hypothalamic GT1-7 Neurons. Neuroendocrinology 1994, 59: 309-317. PMID: 7911229, DOI: 10.1159/000126672.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCells, CulturedCycloleucineExcitatory Amino Acid AntagonistsFura-2GlutamatesGlutamic AcidGonadotropin-Releasing HormoneHypothalamusInositol PhosphatesMiceMice, TransgenicNeuronsNeurotoxinsReceptors, AMPAReceptors, GlutamateReceptors, N-Methyl-D-AspartateSpectrometry, FluorescenceConceptsDichlorokynurenic acidGnRH secretionMK-801Immortalized hypothalamic GT1-7 neuronsGonadotropin-Releasing Hormone SecretionOxo-4-isoxazolepropanoic acidAMPA/kainate antagonistGT1-7 cell lineAction of glutamateReceptor subtype agonistsNMDA receptor antagonistConcentration-dependent riseGT1-7 neuronsGT1-7 cellsKainate antagonistSubtype agonistsHormone secretionHypothalamic neuronsReceptor antagonistGlutamate actionSecretory responseNMDA receptorsGlycine siteCyclopentanedicarboxylic acidNeuroendocrine regulation