1993
Differential modulation by extracellular ATP of carotid chemosensory responses
Spergel D, Lahiri S. Differential modulation by extracellular ATP of carotid chemosensory responses. Journal Of Applied Physiology 1993, 74: 3052-3056. PMID: 8366007, DOI: 10.1152/jappl.1993.74.6.3052.Peer-Reviewed Original ResearchConceptsCarotid bodyO2 chemoreceptionCarotid chemosensory responsesChemosensory responsesChemosensory dischargeATP administrationNeurotransmitter levelsPentobarbital sodiumATP receptorsNicotinic receptorsTyrode's solutionSimilar dose dependenceExtracellular ATPNicotineInitial stimulationDifferential modulationReceptorsSurface receptorsHypoxiaDose dependenceResponseChemoreceptionInfusionMetabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine
Spergel D. Metabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine. Advances In Experimental Medicine And Biology 1993, 337: 221-225. PMID: 7906483, DOI: 10.1007/978-1-4615-2966-8_31.ChaptersConceptsCarotid body preparationCarotid bodyMetabolic substratesCarotid chemosensory responsesMM glucoseProgressive deteriorationBody preparationChemosensory responsivenessGlutamateChemosensory responsesSaline solutionAmino acidsTricarboxylic acid cycle intermediatesResponsivenessCellular energy productionATP generationGlucoseCycle intermediatesNicotineHypoxia
1992
Dependence of carotid chemosensory responses on metabolic substrates
Spergel D, Lahiri S, Wilson D. Dependence of carotid chemosensory responses on metabolic substrates. Brain Research 1992, 596: 80-88. PMID: 1361420, DOI: 10.1016/0006-8993(92)91535-m.Peer-Reviewed Original ResearchConceptsCarotid chemosensory responsesLactic acidosisO2 chemoreceptionChemosensory responsesCat carotid bodyMetabolic substratesConcentration-dependent fashionNicotine injectionCarotid bodyTyrode's solutionNicotineMM glucoseHypoxic responseAcidosisHypoxiaGlucoseGlutamateAmino acidsResponseInterruptionChemoreceptionOxidative deamination
1991
In vitro perfused-superfused cat carotid body for physiological and pharmacological studies
Iturriaga R, Rumsey WL, Mokashi A, Spergel D, Wilson DF, Lahiri S. In vitro perfused-superfused cat carotid body for physiological and pharmacological studies. Journal Of Applied Physiology 1991, 70: 1393-1400. PMID: 1903380, DOI: 10.1152/jappl.1991.70.3.1393.Peer-Reviewed Original ResearchConceptsChemosensory dischargeCarotid bodyPentobarbital sodium-anesthetized catsWhole carotid sinus nerveCarotid sinus nerveInjections of nicotineCarotid body preparationCat carotid bodyRestoration of flowDose-dependent mannerSinus nerveNormoxic perfusionPerfusate PO2Pharmacological stimuliPerfusate flowInitial responsivenessTyrode's solutionPharmacological studiesCarotid bifurcationPerfusionCO2 stimulusBasal activityChemosensory responsesNicotineBody preparation