1995
L-Type Ca2+ Channels Mediate Joint Modulation by Gamma-Amino-butyric Acid and Glutamate of [Ca2+]i and Neuropeptide Secretion in Immortalized Gonadodropin-Releasing Hormone Neurons
Spergel D, Krsmanovic L, Stojilkovic S, Catt K. L-Type Ca2+ Channels Mediate Joint Modulation by Gamma-Amino-butyric Acid and Glutamate of [Ca2+]i and Neuropeptide Secretion in Immortalized Gonadodropin-Releasing Hormone Neurons. Neuroendocrinology 1995, 61: 499-508. PMID: 7617127, DOI: 10.1159/000126873.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidReceptor antagonistReceptor agonistSecretory responseGonadotropin-releasing hormone (GnRH) secretionGlutamate-induced Ca2GnRH secretory responseImmortalized GnRH neuronsGABAB receptor antagonistGABAA receptor antagonistGABAB receptor agonistGABAA receptor agonistL-type Ca2GT1-7 neuronsHormone neuronsGnRH neuronsRole of calciumHormone secretionGamma-AminoNeuropeptide secretionAgonist concentrationsCytoplasmic calciumNeuronsFree mediumGlutamate
1993
Metabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine
Spergel D. Metabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine. Advances In Experimental Medicine And Biology 1993, 337: 221-225. PMID: 7906483, DOI: 10.1007/978-1-4615-2966-8_31.ChaptersConceptsCarotid body preparationCarotid bodyMetabolic substratesCarotid chemosensory responsesMM glucoseProgressive deteriorationBody preparationChemosensory responsivenessGlutamateChemosensory responsesSaline solutionAmino acidsTricarboxylic acid cycle intermediatesResponsivenessCellular energy productionATP generationGlucoseCycle intermediatesNicotineHypoxia
1992
Dependence of carotid chemosensory responses on metabolic substrates
Spergel D, Lahiri S, Wilson D. Dependence of carotid chemosensory responses on metabolic substrates. Brain Research 1992, 596: 80-88. PMID: 1361420, DOI: 10.1016/0006-8993(92)91535-m.Peer-Reviewed Original ResearchConceptsCarotid chemosensory responsesLactic acidosisO2 chemoreceptionChemosensory responsesCat carotid bodyMetabolic substratesConcentration-dependent fashionNicotine injectionCarotid bodyTyrode's solutionNicotineMM glucoseHypoxic responseAcidosisHypoxiaGlucoseGlutamateAmino acidsResponseInterruptionChemoreceptionOxidative deamination