2004
Neurotrophic effects of BDNF on embryonic gonadotropin‐releasing hormone (GnRH) neurons
Cronin AS, Horan TL, Spergel DJ, Brooks AN, Hastings MH, Ebling FJ. Neurotrophic effects of BDNF on embryonic gonadotropin‐releasing hormone (GnRH) neurons. European Journal Of Neuroscience 2004, 20: 338-344. PMID: 15233743, DOI: 10.1111/j.1460-9568.2004.03490.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain-Derived Neurotrophic FactorCell CountCells, CulturedCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianGonadotropin-Releasing HormoneGreen Fluorescent ProteinsImmunoenzyme TechniquesImmunohistochemistryLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicMitogen-Activated Protein KinasesNeuritesNeuronsOligodeoxyribonucleotides, AntisensePotassium ChlorideReceptor, trkBConceptsBrain-derived neurotrophic factorGnRH cellsNeurotrophic factorMedian eminenceGonadotropin-releasing hormone (GnRH) neuronsNeurite outgrowthGnRH secretory systemGnRH-immunoreactive cellsGonadotropin-releasing hormoneDose-dependent increaseResponse element-binding proteinPhosphorylation of ERKHormone neuronsBDNF treatmentGnRH neuronsNeurotrophic effectsPreoptic areaNeurons migrateReproductive axisElement-binding proteinOlfactory placodeOlfactory tissuePrimary culturesERK pathwayGnRH
1995
Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells.
Bagnato A, Tecce R, Moretti C, Di Castro V, Spergel D, Catt K. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells. Clinical Cancer Research 1995, 1: 1059-66. PMID: 9816080.Peer-Reviewed Original ResearchConceptsOvarian carcinoma cellsHuman ovarian carcinoma cellsET-1ETA receptorsEndothelin-1Carcinoma cellsTumor cellsCell linesGrowth factorCertain ovarian tumorsET-1 participatesReceptor-mediated actionsOVCA 433 cellsOvarian tumor cell linesCalcium signalingDose-dependent increaseRadioligand binding studiesOvarian tumor cellsAutocrine growth factorOvarian cancer cellsSites/cellBasal growth rateAuthentic ET-1BQ-123ET receptors