1993
Differential modulation by extracellular ATP of carotid chemosensory responses
Spergel D, Lahiri S. Differential modulation by extracellular ATP of carotid chemosensory responses. Journal Of Applied Physiology 1993, 74: 3052-3056. PMID: 8366007, DOI: 10.1152/jappl.1993.74.6.3052.Peer-Reviewed Original ResearchConceptsCarotid bodyO2 chemoreceptionCarotid chemosensory responsesChemosensory responsesChemosensory dischargeATP administrationNeurotransmitter levelsPentobarbital sodiumATP receptorsNicotinic receptorsTyrode's solutionSimilar dose dependenceExtracellular ATPNicotineInitial stimulationDifferential modulationReceptorsSurface receptorsHypoxiaDose dependenceResponseChemoreceptionInfusionOptical Measurements of Micro-Vascular Oxygen Pressure and Intracellular pH in the Cat Carotid Body: Testing Hypotheses of Oxygen Chemoreception
Rumsey WL, Iturriaga R, Spergel D, Lahiri S, Wilson DF. Optical Measurements of Micro-Vascular Oxygen Pressure and Intracellular pH in the Cat Carotid Body: Testing Hypotheses of Oxygen Chemoreception. Advances In Experimental Medicine And Biology 1993, 337: 197-203. PMID: 8109402, DOI: 10.1007/978-1-4615-2966-8_28.ChaptersMetabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine
Spergel D. Metabolic Substrate Dependence of Carotid Chemosensory Responses To Stop-Flow Evoked Hypoxia and to Nicotine. Advances In Experimental Medicine And Biology 1993, 337: 221-225. PMID: 7906483, DOI: 10.1007/978-1-4615-2966-8_31.ChaptersConceptsCarotid body preparationCarotid bodyMetabolic substratesCarotid chemosensory responsesMM glucoseProgressive deteriorationBody preparationChemosensory responsivenessGlutamateChemosensory responsesSaline solutionAmino acidsTricarboxylic acid cycle intermediatesResponsivenessCellular energy productionATP generationGlucoseCycle intermediatesNicotineHypoxia
1992
Dependence of carotid chemosensory responses on metabolic substrates
Spergel D, Lahiri S, Wilson D. Dependence of carotid chemosensory responses on metabolic substrates. Brain Research 1992, 596: 80-88. PMID: 1361420, DOI: 10.1016/0006-8993(92)91535-m.Peer-Reviewed Original ResearchConceptsCarotid chemosensory responsesLactic acidosisO2 chemoreceptionChemosensory responsesCat carotid bodyMetabolic substratesConcentration-dependent fashionNicotine injectionCarotid bodyTyrode's solutionNicotineMM glucoseHypoxic responseAcidosisHypoxiaGlucoseGlutamateAmino acidsResponseInterruptionChemoreceptionOxidative deaminationIntracellular pH and oxygen chemoreception in the cat carotid body in vitro
Iturriaga R, Rumsey WL, Lahiri S, Spergel D, Wilson DF. Intracellular pH and oxygen chemoreception in the cat carotid body in vitro. Journal Of Applied Physiology 1992, 72: 2259-2266. PMID: 1629081, DOI: 10.1152/jappl.1992.72.6.2259.Peer-Reviewed Original Research
1991
Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body
Rumsey WL, Iturriaga R, Spergel D, Lahiri S, Wilson DF. Optical measurements of the dependence of chemoreception on oxygen pressure in the cat carotid body. American Journal Of Physiology 1991, 261: c614-c622. PMID: 1928325, DOI: 10.1152/ajpcell.1991.261.4.c614.Peer-Reviewed Original ResearchConceptsCarotid bodyCat carotid bodyChemosensory dischargeCarotid arteryCarotid sinus nerve dischargeSinus nerve dischargeCommon carotid arteryTorr/sMicrovascular PO2Nerve dischargeOxygen-dependent quenchingNeural dischargePerfusate flowTyrode's solutionIntravascular PO2Oxygen metabolismOxygen chemoreceptionPerfusateNeural activityArteryExchange vesselsPO2 valuesPO2Brief interruptionIn vitro perfused-superfused cat carotid body for physiological and pharmacological studies
Iturriaga R, Rumsey WL, Mokashi A, Spergel D, Wilson DF, Lahiri S. In vitro perfused-superfused cat carotid body for physiological and pharmacological studies. Journal Of Applied Physiology 1991, 70: 1393-1400. PMID: 1903380, DOI: 10.1152/jappl.1991.70.3.1393.Peer-Reviewed Original ResearchConceptsChemosensory dischargeCarotid bodyPentobarbital sodium-anesthetized catsWhole carotid sinus nerveCarotid sinus nerveInjections of nicotineCarotid body preparationCat carotid bodyRestoration of flowDose-dependent mannerSinus nerveNormoxic perfusionPerfusate PO2Pharmacological stimuliPerfusate flowInitial responsivenessTyrode's solutionPharmacological studiesCarotid bifurcationPerfusionCO2 stimulusBasal activityChemosensory responsesNicotineBody preparation
1990
Phosphorescence and Fluorescence Imaging: New Tools for the Study of Carotid Body Function
Rumsey W, Iturriaga R, Wilson D, Lahiri S, Spergel D. Phosphorescence and Fluorescence Imaging: New Tools for the Study of Carotid Body Function. 1990, 73-79. DOI: 10.1007/978-1-4684-8938-5_10.Chapters