Trends in the “Off-Label” Use of GnRH Agonists Among Pediatric Patients in the United States
Lopez CM, Solomon D, Boulware SD, Christison-Lagay E. Trends in the “Off-Label” Use of GnRH Agonists Among Pediatric Patients in the United States. Clinical Pediatrics 2018, 57: 1432-1435. PMID: 30003804, DOI: 10.1177/0009922818787260.Peer-Reviewed Original ResearchConceptsPediatric Health Information SystemGnRH agonistLabel indicationsPrecocious pubertyGnRH agonist therapyOff-label treatmentOff-label useProportion of childrenFraction of childrenHistrelin acetateLupron injectionsAgonist therapyPediatric patientsHormone agonistChildren's HospitalLabel usePrivate insurance coverageMedicaid patientsLabel usesNumber of childrenOff labelStable cohortHealth information systemsAgonistsPatientsTrends in the use of puberty blockers among transgender children in the United States
Lopez CM, Solomon D, Boulware SD, Christison-Lagay ER. Trends in the use of puberty blockers among transgender children in the United States. Journal Of Pediatric Endocrinology And Metabolism 2018, 31: 665-670. PMID: 29715194, DOI: 10.1515/jpem-2018-0048.Peer-Reviewed Original ResearchConceptsPediatric Health Information SystemCentral precocious pubertyHistrelin acetatePrecocious pubertyMinority patientsWhite non-Hispanic patientsOlder ageNon-Hispanic patientsDistribution of patientsPotential racial disparitiesMajority of childrenBilling diagnosisPatient populationTransgender patientsLarge cohortPatientsAverage ageTreatment dataCommercial insuranceHealth information systemsTransgender careNatal femalesRacial disparitiesDiagnosisNational trends