Interleukin‐2 enhances biopterins and catecholamines production during adoptive immunotherapy for various cancers
Baker H, Marcus S, Frank O, Petrylak D, Deangelis B, Dutcher J, Wiernik P. Interleukin‐2 enhances biopterins and catecholamines production during adoptive immunotherapy for various cancers. Cancer 1989, 64: 1226-1231. PMID: 2788491, DOI: 10.1002/1097-0142(19890915)64:6<1226::aid-cncr2820640611>3.0.co;2-m.Peer-Reviewed Original ResearchConceptsIL-2 treatmentAdoptive immunotherapyInterleukin-2Biopterin productionPlasma biopterinMetastatic renal cell carcinomaIL-2 activationIL-2 exposureAdoptive immunotherapy protocolsMetastatic colon cancerRenal cell carcinomaLAK treatmentImmunotherapy protocolsKiller cellsLAK cellsImmunotherapy treatmentCell carcinomaPlasma catecholaminesTumor regressionCatecholamine productionMalignant melanomaLeukocyte populationsTotal biopterinLeukocyte activationImmunotherapy