2020
The association of humoral antigen spread (AgS) with cytotoxic T lymphocyte (CTL) activity after sipuleucel-T (sip-T) treatment in two phase II clinical studies: STAMP and STRIDE.
Petrylak D, Antonarakis E, Kandadi H, Fong L, Lance R, Vu T, Sheikh N, Shore N, Drake C. The association of humoral antigen spread (AgS) with cytotoxic T lymphocyte (CTL) activity after sipuleucel-T (sip-T) treatment in two phase II clinical studies: STAMP and STRIDE. Journal Of Clinical Oncology 2020, 38: 112-112. DOI: 10.1200/jco.2020.38.6_suppl.112.Peer-Reviewed Original ResearchCTL activityAntibody responseAntigen spreadMetastatic castration-resistant prostate cancerCytotoxic T lymphocyte activityCastration-resistant prostate cancerPhase II clinical studyAg responseImproved overall survivalSipuleucel-T treatmentSpecific CTL activityTumor immunity cycleT lymphocyte activityII clinical studySecondary antibody responseRank testSpearman rank testCD107a expressionSpecific CD8Immunity cycleOverall survivalLymphocyte activityAntigen responseMultiple time pointsProstate cancer
2017
Antigen spread (AgS) after sipuleucel-T (sip-T): A cross-trial comparison of 4 sip-T clinical trials of patients (pts) with prostate cancer (PC).
Fong L, Small E, Petrylak D, Quinn D, Antonarakis E, Kibel A, Chang N, Kandadi H, Sheikh N, Drake C. Antigen spread (AgS) after sipuleucel-T (sip-T): A cross-trial comparison of 4 sip-T clinical trials of patients (pts) with prostate cancer (PC). Journal Of Clinical Oncology 2017, 35: 143-143. DOI: 10.1200/jco.2017.35.6_suppl.143.Peer-Reviewed Original ResearchMetastatic castration-resistant PCProstatic acid phosphataseProstate cancerIgG responsesDisease courseSymptomatic metastatic castration-resistant prostate cancerMetastatic castration-resistant prostate cancerAntigen-presenting cell activationCastration-resistant prostate cancerPeripheral blood mononuclear cellsAndrogen-dependent prostate cancerBlood mononuclear cellsCross-trial comparisonsCancer-related antigensGranulocyte-macrophage colony-stimulating factorMacrophage colony-stimulating factorColony-stimulating factorImproved OSAndrogen suppressionClinical benefitAutologous immunotherapyDisease stageMononuclear cellsAntibody responseClinical trials