Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
Ayalew M, Le-Niculescu H, Levey DF, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon D, Schork NJ, Fanous AH, O'Donovan MC, Niculescu AB. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Molecular Psychiatry 2012, 17: 887-905. PMID: 22584867, PMCID: PMC3427857, DOI: 10.1038/mp.2012.37.Peer-Reviewed Original ResearchConceptsTop candidate genesCandidate genesG protein-coupled receptor signalingGenome-wide association study dataFunctional genomics approachReceptor signalingConvergent functional genomics approachAssociation study dataGene expression studiesFunctional genomicsGenomic approachesGlutamate receptor signalingSignificant genetic overlapSingle nucleotide polymorphismsEnvironmental stressTop genesExpression studiesPathway analysisBiological pathwaysGenetic risk predictionGenesCell adhesionBiological landscapeGenetic overlapSignaling