2022
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells
Lynall ME, Soskic B, Hayhurst J, Schwartzentruber J, Levey DF, Pathak GA, Polimanti R, Gelernter J, Stein MB, Trynka G, Clatworthy MR, Bullmore E. Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells. Nature Communications 2022, 13: 6102. PMID: 36243721, PMCID: PMC9569335, DOI: 10.1038/s41467-022-33885-7.Peer-Reviewed Original ResearchConceptsMultiple psychiatric disordersPsychiatric disordersPsychiatric risk variantT cellsLymphoid cellsRisk variantsImmune cell subsetsMental health disordersMultiple organ systemsAdaptive immune systemCell subsetsImmune cellsHealth disordersMyeloid cellsImmune systemBrain tissueOrgan systemsSpecific disordersDisordersPathogenesisAbnormalitiesGenetic variantsCellsCD4Variants
2021
Integrating Human Brain Proteomes With Genome-Wide Association Results Identify Novel Brain Proteins in PTSD Pathogenesis
Wingo T, Gerasimov E, Liu Y, Duong D, Lori A, Gockley J, Toikumo S, Breen M, Maihofer A, Nievergelt C, Koenen K, Ressler K, Levey D, Gelernter J, Stein M, Bennett D, Levey A, Seyfried N, Wingo A. Integrating Human Brain Proteomes With Genome-Wide Association Results Identify Novel Brain Proteins in PTSD Pathogenesis. Biological Psychiatry 2021, 89: s102-s103. DOI: 10.1016/j.biopsych.2021.02.265.Peer-Reviewed Original Research