2021
Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy
Hegde SM, Lester SJ, Solomon SD, Michels M, Elliott PM, Nagueh SF, Choudhury L, Zemanek D, Zwas DR, Jacoby D, Wang A, Ho CY, Li W, Sehnert AJ, Olivotto I, Abraham TP. Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy. Journal Of The American College Of Cardiology 2021, 78: 2518-2532. PMID: 34915982, DOI: 10.1016/j.jacc.2021.09.1381.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySystolic anterior motionAnterior motionDiastolic functionHypertrophic cardiomyopathyN-terminal pro-B-type natriuretic peptideMitral valve systolic anterior motionPro-B-type natriuretic peptidePeak exercise oxygen consumptionLeft ventricular diastolic functionVentricular outflow tract obstructionKey echocardiographic parametersAtrial volume indexOutflow tract obstructionVentricular diastolic functionExercise oxygen consumptionEffect of mavacamtenMyocardial wall stressEXPLORER-HCMLVOT gradientEchocardiographic featuresEchocardiographic parametersLVOT obstructionTract obstructionExercise capacity
2020
Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy
Ho CY, Mealiffe ME, Bach RG, Bhattacharya M, Choudhury L, Edelberg JM, Hegde SM, Jacoby D, Lakdawala NK, Lester SJ, Ma Y, Marian AJ, Nagueh SF, Owens A, Rader F, Saberi S, Sehnert AJ, Sherrid MV, Solomon SD, Wang A, Wever-Pinzon O, Wong TC, Heitner SB. Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy. Journal Of The American College Of Cardiology 2020, 75: 2649-2660. PMID: 32466879, DOI: 10.1016/j.jacc.2020.03.064.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBenzylaminesBiomarkersCardiomyopathy, HypertrophicDouble-Blind MethodEchocardiographyFemaleHumansMaleMiddle AgedUracilConceptsNonobstructive hypertrophic cardiomyopathyGeometric mean differencePlacebo groupHypertrophic cardiomyopathyN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptidePg/Mean differencePhase II studySerious adverse eventsVentricular ejection fractionMyocardial wall stressDose titrationNT-proBNPAdverse eventsII studySymptomatic patientsEjection fractionPharmacological therapyClinical parametersInitial doseNatriuretic peptideMean ageHigh burdenMavacamtenZinc Deficiency as a Reversible Cause of Heart Failure.
Rosenblum H, Bikdeli B, Wessler J, Gupta A, Jacoby DL. Zinc Deficiency as a Reversible Cause of Heart Failure. Texas Heart Institute Journal 2020, 47: 152-154. PMID: 32603465, PMCID: PMC7328074, DOI: 10.14503/thij-17-6586.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAnorexia NervosaBiomarkersEchocardiographyFemaleHeart FailureHeart VentriclesHumansMalnutritionYoung AdultZincConceptsHeart failureZinc supplementationDepressed left ventricular systolic functionNew-onset heart failureLeft ventricular systolic functionZinc levelsLow plasma zinc levelsZinc deficiencyVentricular systolic functionPlasma zinc levelsCross-sectional studyCardiomyocyte oxidative stressOngoing pathogenesisReversible causesSystolic functionLower plasmaMyocardial structureNutritional deficienciesAnorexia nervosaOxidative stressPatientsSupplementationChief causeDeficiencyFailure
2019
Mulibrey Nanism Syndrome: A Case for Heart Transplantation
Anwer M, Bin Mahmood SU, Stawiarski K, Elder R, Ali A, Jacoby D. Mulibrey Nanism Syndrome: A Case for Heart Transplantation. The Annals Of Thoracic Surgery 2019, 109: e115-e117. PMID: 31260650, DOI: 10.1016/j.athoracsur.2019.05.021.Peer-Reviewed Case Reports and Technical NotesRisk score for the exclusion of arrhythmic events in arrhythmogenic right ventricular cardiomyopathy at first presentation
Vischer AS, Castelletti S, Syrris P, Bastiaenen R, Miles C, Akdis D, Denhaerynck K, Jacoby D, Saguner AM, Krahn AD, Behr ER, McKenna WJ, Pantazis A. Risk score for the exclusion of arrhythmic events in arrhythmogenic right ventricular cardiomyopathy at first presentation. International Journal Of Cardiology 2019, 290: 100-105. PMID: 31104822, DOI: 10.1016/j.ijcard.2019.04.090.Peer-Reviewed Original ResearchConceptsArrhythmogenic right ventricular cardiomyopathyNon-sustained VTNegative T wavesRight ventricular cardiomyopathyVentricular arrhythmiasRisk scoreArrhythmic eventsFiltered QRS durationFirst presentationH ECGQRS durationVentricular cardiomyopathyLead aVRARVC Task Force CriteriaApplicable risk scoreCohort of patientsSustained ventricular arrhythmiasMultivariable logistic regressionTask Force criteriaDetailed clinical dataLife-threatening arrhythmiasHeart muscle disorderT waveNegative predictive valueSignal-averaged ECG