2021
Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection
Weiss JJ, Attuquayefio TN, White EB, Li F, Herz RS, White TL, Campbell M, Geng B, Datta R, Wyllie AL, Grubaugh ND, Casanovas-Massana A, Muenker MC, Moore AJ, Handoko R, Iwasaki A, Martinello RA, Ko AI, Small DM, Farhadian SF, Team T. Tracking smell loss to identify healthcare workers with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0248025. PMID: 33657167, PMCID: PMC7928484, DOI: 10.1371/journal.pone.0248025.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2 positive healthcare workersSmell lossHealthcare workersHome assessmentNeurological symptomsPositive SARS-CoV-2 testSARS-CoV-2 test positivitySARS-CoV-2 testPolymerase chain reaction testingReal-time quantitative polymerase chain reaction testingQuantitative polymerase chain reaction testingCOVID-19 patientsHigh-risk groupHigh-risk individualsSARS-CoV-2Self-reported changesProspective studyTest positivityAsymptomatic infectionSymptom SurveyVulnerable patientsHigh riskPositive testRisk individualsPost-traumatic olfactory loss and brain response beyond olfactory cortex
Pellegrino R, Farruggia MC, Small DM, Veldhuizen MG. Post-traumatic olfactory loss and brain response beyond olfactory cortex. Scientific Reports 2021, 11: 4043. PMID: 33597627, PMCID: PMC7889874, DOI: 10.1038/s41598-021-83621-2.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexOlfactory impairmentOlfactory cortexFunctional anosmiaPost-traumatic olfactory lossPrimary olfactory areasWhole-brain responsesBrain responsesGray matter densityHigher-order areasOlfactory lossPiriform cortexHead traumaHealthy controlsOlfactory areasOdorless stimuliOlfactory functionMediodorsal thalamusCortical areasVentromedial prefrontal cortexCingulate cortexFrontal operculumCortexAnterior insulaPrefrontal cortex
2020
Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism 2020, 31: 493-502.e7. PMID: 32130881, PMCID: PMC7784207, DOI: 10.1016/j.cmet.2020.01.014.Peer-Reviewed Original ResearchConceptsGlucose metabolismPrevalence of obesityType 2 diabetesSugar-sweetened beveragesConsumption of sucraloseHealthy human participantsInsulin sensitivityTerm consumptionTaste perceptionMetabolismLong-term decreaseSweet tasteMetabolic sensitivityComorbiditiesGeneral consensusObesityDiabetesHuman participantsBeveragesMidbrainPrevalenceBrainSimilar relationship
2018
Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans
Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metabolism 2018, 29: 695-706.e4. PMID: 30595479, DOI: 10.1016/j.cmet.2018.12.006.Peer-Reviewed Original ResearchConceptsDopaminergic circuitsHigher cognitive centersSegregated brain regionsPeripheral physiological signalsPalatable food intakeReward valueDopamine releaseCognitive centersSubjective desireBrain regionsBrain areasUnderlying reinforcementFood intakeDorsal striatumRole of brainPhysiological signalsFood selection behaviorIntegrative pathwaysFMRIDesirePET methodBrainHumansIntakeSelection behaviorSweet taste potentiates the reinforcing effects of e-cigarettes
Kroemer NB, Veldhuizen MG, Delvy R, Patel BP, O'Malley SS, Small DM. Sweet taste potentiates the reinforcing effects of e-cigarettes. European Neuropsychopharmacology 2018, 28: 1089-1102. PMID: 30093174, DOI: 10.1016/j.euroneuro.2018.07.102.Peer-Reviewed Original Research
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic stateInteraction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Heni M, Kullmann S, Ahlqvist E, Wagner R, Machicao F, Staiger H, Häring HU, Almgren P, Groop LC, Small DM, Fritsche A, Preissl H. Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia 2016, 59: 2622-2631. PMID: 27600277, DOI: 10.1007/s00125-016-4095-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdministration, IntranasalAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHumansInsulinInsulin ResistanceMagnetic Resonance SpectroscopyMaleMiddle AgedObesityPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsInsulin sensitivityReceptor densityCaudate nucleusDopamine D2 receptor densityFTO obesity-risk alleleANKK1 polymorphismCentral insulin sensitivityIntranasal insulin administrationPeripheral insulin sensitivityBrain insulin sensitivityRisk of obesityDopamine receptor densityD2 receptor availabilityObesity risk allelesD2 receptor densityTübingen Family studyMalmö DietWaist circumferenceFTO SNP rs8050136FTO variationInsulin administrationD2 receptorsFood intakeBody fatBody composition
2015
Fatty acid amide supplementation decreases impulsivity in young adult heavy drinkers
van Kooten MJ, Veldhuizen MG, de Araujo IE, O'Malley SS, Small DM. Fatty acid amide supplementation decreases impulsivity in young adult heavy drinkers. Physiology & Behavior 2015, 155: 131-140. PMID: 26656766, PMCID: PMC4718847, DOI: 10.1016/j.physbeh.2015.11.032.Peer-Reviewed Original ResearchConceptsGo/No-Go taskHeavy drinkersStriatal extracellular dopamine levelsVagal afferent signalingExtracellular dopamine levelsHeavy drinking young adultsAlcohol intakeAdult heavy drinkersSupplementation regimenAfferent signalingYoung adult heavy drinkersDopamine levelsSelf-report questionnairesDecrease impulsivityTherapeutic potentialDietary supplementsIntragastric infusionAlcohol useYoung adultsFatty acid amidesPlaceboPreliminary evidenceBehavioral tasksImpulsive respondingImpulsive behavior
2013
Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions
2012
Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress
Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. International Journal Of Obesity 2012, 37: 309-316. PMID: 22430303, PMCID: PMC3381866, DOI: 10.1038/ijo.2012.39.Peer-Reviewed Original ResearchConceptsBody mass indexFunctional magnetic resonance imagingChronic stressOrbitofrontal cortexRight amygdalaBody weightPalatable foodAcute stressBasal cortisol levelsBrain responsesAmygdala responseMagnetic resonance imagingStress-related eatingMilkshake receiptPalatable milkshakeObese womenOverweight womenMass indexRight amygdala responseOFC responsesPotentiates responsesCortisol levelsLeft amygdalaResonance imagingVentral striatum
2010
Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula
Rudenga K, Green B, Nachtigal D, Small DM. Evidence for an Integrated Oral Sensory Module in the Human Anterior Ventral Insula. Chemical Senses 2010, 35: 693-703. PMID: 20595201, PMCID: PMC2943409, DOI: 10.1093/chemse/bjq068.Peer-Reviewed Original ResearchConceptsAnterior ventral insulaVentral insulaOral stimulationTasteless control solutionFunctional magnetic resonanceVentral pallidumPhysiological significanceHarmful stimuliInsular responsesInsulaOral sensationNutritive stimulusModalitiesDifferential connectivityPresent studyStimulationMagnetic resonanceSensory modalitiesSubjectsHypothalamusStimuliStriatumPallidum
2008
Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment
Bagurdes LA, Mesulam MM, Gitelman DR, Weintraub S, Small DM. Modulation of the spatial attention network by incentives in healthy aging and mild cognitive impairment. Neuropsychologia 2008, 46: 2943-2948. PMID: 18602410, DOI: 10.1016/j.neuropsychologia.2008.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAnalysis of VarianceAttentionCase-Control StudiesCerebral CortexCognition DisordersDementiaDiscrimination, PsychologicalHumansLimbic SystemMagnetic Resonance ImagingMatched-Pair AnalysisMiddle AgedMotivationReaction TimeReference ValuesRewardSeverity of Illness IndexSpace PerceptionConceptsSpatial attentionSpatial attention networkAttentional shiftsMild cognitive impairmentAttention networkHealthy agingOrbitofrontal cortexCovert attention taskSelective spatial attentionCognitive impairmentUnderlying neural circuitryAD-related declineAttention taskSelective attentionEmotional contentOFC activationPCC activationSpatial cuesSecondary reinforcerInfluence of incentivesPosterior cingulateNeural circuitryNovel eventsCurrent experimentsBehavioral effects
2005
Increased taste intensity perception exhibited by patients with chronic back pain
Small DM, Apkarian A. Increased taste intensity perception exhibited by patients with chronic back pain. Pain 2005, 120: 124-130. PMID: 16360267, DOI: 10.1016/j.pain.2005.10.021.Peer-Reviewed Original ResearchConceptsChronic back painCBP patientsBack painControl subjectsSpecific brain sitesSpecific brain abnormalitiesSuprathreshold taste intensityCortical injuryTaste disturbanceBrain atrophyTaste intensity perceptionPain perceptionBrain abnormalitiesBrain sitesPainBrain regionsSense of tastePatientsGustatory stimuliBitter stimuliRecognition thresholdSubjectsVisual assessmentFurther evidenceSpecific patternsTaste and Olfactory Intensity Perception Changes Following Left Insular Stroke
Mak YE, Simmons KB, Gitelman DR, Small DM. Taste and Olfactory Intensity Perception Changes Following Left Insular Stroke. Behavioral Neuroscience 2005, 119: 1693-1700. PMID: 16420174, DOI: 10.1037/0735-7044.119.6.1693.Peer-Reviewed Original Research
2001
Increased intensity perception of aversive taste following right anteromedial temporal lobe removal in humans
Small D, Zatorre R, Jones-Gotman M. Increased intensity perception of aversive taste following right anteromedial temporal lobe removal in humans. Brain 2001, 124: 1566-1575. PMID: 11459748, DOI: 10.1093/brain/124.8.1566.Peer-Reviewed Original ResearchChanges in Taste Intensity Perception Following Anterior Temporal Lobe Removal in Humans
Small D, Zatorre R, Jones-Gotman M. Changes in Taste Intensity Perception Following Anterior Temporal Lobe Removal in Humans. Chemical Senses 2001, 26: 425-432. PMID: 11369677, DOI: 10.1093/chemse/26.4.425.Peer-Reviewed Original ResearchConceptsAnterior temporal lobeTemporal lobeHealthy control subjectsTemporal lobe removalsRight anterior temporal lobeRight temporal groupPatient groupIntractable epilepsyControl subjectsControl groupMeasures ANOVAMeasures analysisBitter tasteSignificant differencesUnpleasant bitter tasteStimulus concentrationLobeTaste perceptionSubjectsGroupTemporal groupsPatientsIntensity perceptionEpilepsy
1997
A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition
Small D, Jones-Gotman M, Zatorre R, Petrides M, Evans A. A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition. Journal Of Neuroscience 1997, 17: 5136-5142. PMID: 9185551, PMCID: PMC6573307, DOI: 10.1523/jneurosci.17-13-05136.1997.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowAnteromedial temporal lobeGroup of patientsTemporal lobeRight anterior temporal lobectomyOrbitofrontal cortexCaudolateral orbitofrontal cortexAnterior temporal lobectomyCerebral blood flowRight anterior temporal lobePrimary taste cortexTreatment of epilepsyPositron emission tomographyRight cerebral hemisphereAnterior temporal lobeRCBF increasesTemporal lobectomyGustatory functionTaste cortexBlood flowCerebral hemispheresControl groupEmission tomographyPatientsTaste sensation