2020
Central nervous pathways of insulin action in the control of metabolism and food intake
Kullmann S, Kleinridders A, Small DM, Fritsche A, Häring HU, Preissl H, Heni M. Central nervous pathways of insulin action in the control of metabolism and food intake. The Lancet Diabetes & Endocrinology 2020, 8: 524-534. PMID: 32445739, DOI: 10.1016/s2213-8587(20)30113-3.Peer-Reviewed Original ResearchConceptsPalatable food cuesCentral insulin actionCurrent findingsInsulin actionCognitive controlFood cuesCognitive healthPeripheral metabolismFood intakeMesocorticolimbic circuitryBrain insulin actionWhole-body insulin sensitivityCentral nervous pathwaysType 2 diabetesHuman researchCognitive diseasesEndogenous glucose productionDopamine systemNervous pathwaysTherapeutic optionsInsulin sensitivitySystemic metabolismAnimal modelsGlucose productionControl of metabolism
2016
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Heni M, Kullmann S, Ahlqvist E, Wagner R, Machicao F, Staiger H, Häring HU, Almgren P, Groop LC, Small DM, Fritsche A, Preissl H. Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia 2016, 59: 2622-2631. PMID: 27600277, DOI: 10.1007/s00125-016-4095-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdministration, IntranasalAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHumansInsulinInsulin ResistanceMagnetic Resonance SpectroscopyMaleMiddle AgedObesityPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsInsulin sensitivityReceptor densityCaudate nucleusDopamine D2 receptor densityFTO obesity-risk alleleANKK1 polymorphismCentral insulin sensitivityIntranasal insulin administrationPeripheral insulin sensitivityBrain insulin sensitivityRisk of obesityDopamine receptor densityD2 receptor availabilityObesity risk allelesD2 receptor densityTübingen Family studyMalmö DietWaist circumferenceFTO SNP rs8050136FTO variationInsulin administrationD2 receptorsFood intakeBody fatBody composition
2013
Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions