2020
No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
Vosseler A, Zhao D, Fritsche L, Lehmann R, Kantartzis K, Small DM, Peter A, Häring HU, Birkenfeld AL, Fritsche A, Wagner R, Preißl H, Kullmann S, Heni M. No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men. Scientific Reports 2020, 10: 20466. PMID: 33235256, PMCID: PMC7686306, DOI: 10.1038/s41598-020-77430-2.Peer-Reviewed Original ResearchConceptsTranscutaneous auricular vagus nerve stimulationOral glucose tolerance testAuricular vagus nerve stimulationVagus nerve stimulationGlucose tolerance testAutonomic nervous systemNerve stimulationCatecholamine levelsTolerance testNervous systemHealthy lean menCross-over studyHeart rate variability parametersCross-over designWhole-body metabolismHeart rate variabilityMajor regulatory effectsLean menAutonomic innervationAutonomic toneHealthy menPlasma glucoseInsulin sensitivityPeripheral organsInsulin secretion
2016
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity
Heni M, Kullmann S, Ahlqvist E, Wagner R, Machicao F, Staiger H, Häring HU, Almgren P, Groop LC, Small DM, Fritsche A, Preissl H. Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia 2016, 59: 2622-2631. PMID: 27600277, DOI: 10.1007/s00125-016-4095-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdministration, IntranasalAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFemaleGenetic Predisposition to DiseaseGenotypeGlucose Tolerance TestHumansInsulinInsulin ResistanceMagnetic Resonance SpectroscopyMaleMiddle AgedObesityPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsInsulin sensitivityReceptor densityCaudate nucleusDopamine D2 receptor densityFTO obesity-risk alleleANKK1 polymorphismCentral insulin sensitivityIntranasal insulin administrationPeripheral insulin sensitivityBrain insulin sensitivityRisk of obesityDopamine receptor densityD2 receptor availabilityObesity risk allelesD2 receptor densityTübingen Family studyMalmö DietWaist circumferenceFTO SNP rs8050136FTO variationInsulin administrationD2 receptorsFood intakeBody fatBody composition