2018
Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans
Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metabolism 2018, 29: 695-706.e4. PMID: 30595479, DOI: 10.1016/j.cmet.2018.12.006.Peer-Reviewed Original ResearchConceptsDopaminergic circuitsHigher cognitive centersSegregated brain regionsPeripheral physiological signalsPalatable food intakeReward valueDopamine releaseCognitive centersSubjective desireBrain regionsBrain areasUnderlying reinforcementFood intakeDorsal striatumRole of brainPhysiological signalsFood selection behaviorIntegrative pathwaysFMRIDesirePET methodBrainHumansIntakeSelection behavior
2007
The Role of the Human Orbitofrontal Cortex in Taste and Flavor Processing
SMALL DM, BENDER G, VELDHUIZEN MG, RUDENGA K, NACHTIGAL D, FELSTED J. The Role of the Human Orbitofrontal Cortex in Taste and Flavor Processing. Annals Of The New York Academy Of Sciences 2007, 1121: 136-151. PMID: 17846155, DOI: 10.1196/annals.1401.002.Peer-Reviewed Original ResearchConceptsHuman orbitofrontal cortexOrbitofrontal cortexSensory inputDistinct sensory inputsMultiple sensory inputsHigher-order gustatory corticesNeural representationFlavor perceptReward valueFlavor processingAffective valueOral somatosensationFood rewardInternal statesPerceptGustatory cortexCortexOrbital cortexRetronasal olfactionProcessingPleasantnessRewardEncodingSomatosensationRepresentation
2001
Changes in brain activity related to eating chocolate
Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M. Changes in brain activity related to eating chocolate. Brain 2001, 124: 1720-1733. PMID: 11522575, DOI: 10.1093/brain/124.9.1720.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowOnly brain regionBrain activityPosterior cingulate cortexNon-specific effectsChemosensory areasBlood flowPET scansCingulate cortexBrain regionsPatterns of activitySensory stimuliFunctional segregationSatietyPiece of chocolateSubjectsReward valueSubjects' ratingsNeural representationSeparate motivational systemsActivityCaudomedialCortex