2018
Sweet taste potentiates the reinforcing effects of e-cigarettes
Kroemer NB, Veldhuizen MG, Delvy R, Patel BP, O'Malley SS, Small DM. Sweet taste potentiates the reinforcing effects of e-cigarettes. European Neuropsychopharmacology 2018, 28: 1089-1102. PMID: 30093174, DOI: 10.1016/j.euroneuro.2018.07.102.Peer-Reviewed Original ResearchAccumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain
Rosenbaum M, Agurs‐Collins T, Bray MS, Hall KD, Hopkins M, Laughlin M, MacLean PS, Maruvada P, Savage CR, Small DM, Stoeckel L. Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain. Obesity 2018, 26: s25-s34. PMID: 29575784, PMCID: PMC6945498, DOI: 10.1002/oby.22156.Peer-Reviewed Original ResearchConceptsObesity treatmentSurgical obesity treatmentAdult obesity treatmentTreatment responseBody compositionEnergy homeostasisObesity researchersBrain structuresObesity researchEvidence baseAccumulating DataWeight loss studiesTreatmentBiological measuresHigh-priority measuresIndividual variabilityKey biological factorsBiological factorsResponsePharmacologicalBiomarkersEnvironmental factorsAccumulation of data
2016
Micturition Drive is Associated with Decreased Brain Response to Palatable Milkshake in the Human Anterior Insular Cortex
Gao X, Sun X, Veldhuizen M, Nakamura Y, Kroemer N, Small D. Micturition Drive is Associated with Decreased Brain Response to Palatable Milkshake in the Human Anterior Insular Cortex. Chemosensory Perception 2016, 9: 174-181. DOI: 10.1007/s12078-016-9215-1.Peer-Reviewed Original ResearchAnterior insular cortexInsular cortexInsular responsesMagnetic resonance imaging studyBrain responsesResonance imaging studyFunctional magnetic resonance imaging studyPalatable milkshakeConclusionThis findingSmall bolusImaging studiesCortexVisceral representationMilkshakePrevious reportsInteroceptive informationTime participantsResponseBolus
2013
Verbal descriptors influence hypothalamic response to low-calorie drinks
Veldhuizen MG, Nachtigal DJ, Flammer LJ, de Araujo IE, Small DM. Verbal descriptors influence hypothalamic response to low-calorie drinks. Molecular Metabolism 2013, 2: 270-280. PMID: 24049739, PMCID: PMC3773823, DOI: 10.1016/j.molmet.2013.06.004.Peer-Reviewed Original Research
2012
Altered hypothalamic response to food in smokers 1 , 2 , 3
Geha PY, Aschenbrenner K, Felsted J, O'Malley SS, Small DM. Altered hypothalamic response to food in smokers 1 , 2 , 3. American Journal Of Clinical Nutrition 2012, 97: 15-22. PMID: 23235196, PMCID: PMC3522134, DOI: 10.3945/ajcn.112.043307.Peer-Reviewed Original ResearchConceptsWeight changeBrain responsesFunctional MRILong-term weight changeAltered brain responsesTasteless control solutionMilk shakeEnergy-dense foodsGroup of ageSmoking statusSmoking cessationSmoking influencesHypothalamic responseNonsmokersSmokersVentral striatumWeight gainBMIHypothalamusGreater responseResponseFoodStudy 1ThalamusGroupThe effect of verbal context on olfactory neural responses
Bensafi M, Croy I, Phillips N, Rouby C, Sezille C, Gerber J, Small DM, Hummel T. The effect of verbal context on olfactory neural responses. Human Brain Mapping 2012, 35: 810-818. PMID: 23225581, PMCID: PMC6869804, DOI: 10.1002/hbm.22215.Peer-Reviewed Original ResearchNeuroimaging the interaction of mind and metabolism in humans
D’Agostino A, Small DM. Neuroimaging the interaction of mind and metabolism in humans. Molecular Metabolism 2012, 1: 10-20. PMID: 24024114, PMCID: PMC3757655, DOI: 10.1016/j.molmet.2012.06.002.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingParticular mental processesNeural circuitsInteraction of mindFood cuesMental processesBrain responsesNeural responsesPsychological stateFunctional neuroimagingNeuroimaging techniquesDecision-making processMagnetic resonance imagingHormonal factorsCuesResonance imagingNeuroimagingMetabolic signalsMindHormonal signalsDesireSatietyBehaviorIntakeResponse
2011
Amygdala response to sucrose consumption is inversely related to artificial sweetener use
Rudenga KJ, Small DM. Amygdala response to sucrose consumption is inversely related to artificial sweetener use. Appetite 2011, 58: 504-507. PMID: 22178008, PMCID: PMC3289048, DOI: 10.1016/j.appet.2011.12.001.Peer-Reviewed Original ResearchModality-Specific Neural Effects of Selective Attention to Taste and Odor
Veldhuizen MG, Small DM. Modality-Specific Neural Effects of Selective Attention to Taste and Odor. Chemical Senses 2011, 36: 747-760. PMID: 21685407, PMCID: PMC3175104, DOI: 10.1093/chemse/bjr043.Peer-Reviewed Original ResearchConceptsPrimary olfactory cortexPrimary taste cortexAnterior insular cortexInsular cortexOlfactory cortexTaste cortexPrimary gustatory cortexFunctional magnetic resonancePrimary olfactoryGustatory cortexModality-specific activationInsular responsesNeural effectsCortexBrain responsesMultimodal regionsTaste perceptionMagnetic resonanceGeneral effectSelective attentionActivationResponse
2010
Increased amygdala response and decreased influence of internal state on amygdala response to food in overweight compared to healthy weight individuals
Chouinard-Decorte F, Felsted J, Small D. Increased amygdala response and decreased influence of internal state on amygdala response to food in overweight compared to healthy weight individuals. Appetite 2010, 54: 639. DOI: 10.1016/j.appet.2010.04.042.Peer-Reviewed Original Research
2009
Neural correlates of evaluative compared with passive tasting
Bender G, Veldhuizen MG, Meltzer JA, Gitelman DR, Small DM. Neural correlates of evaluative compared with passive tasting. European Journal Of Neuroscience 2009, 30: 327-338. PMID: 19614981, PMCID: PMC2776645, DOI: 10.1111/j.1460-9568.2009.06819.x.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexOrbitofrontal cortexPrimary taste cortexLeft lateral orbitofrontal cortexFunctional magnetic resonanceTasteless solutionMaximal responseTaste cortexFunction of taskCortical representationGustatory informationAnterior insulaVentral regionNeural responsesPreferential connectivityAmygdalaNeural correlatesCortexInsulaNeural encodingSubjectsStimulus presenceMagnetic resonanceResponseEarly relay
2008
Flavor and the Formation of Category-Specific Processing in Olfaction
Small D. Flavor and the Formation of Category-Specific Processing in Olfaction. Chemosensory Perception 2008, 1: 136-146. DOI: 10.1007/s12078-008-9015-3.Peer-Reviewed Original ResearchCategory-specific processingOral referralAnterior cingulate cortexRolandic operculumCingulate cortexPattern of responseOrbitofrontal cortexUnimodal tasteFlavor perceptReferralBimodal cellsCortexNeural processingFlavor objectsSensory modalitiesMultiple sensory modalitiesOlfactionCellsPerception of flavorInsulaNeuronsOperculumNeural bindingResponse
2005
Differential Neural Responses Evoked by Orthonasal versus Retronasal Odorant Perception in Humans
Small DM, Gerber JC, Mak YE, Hummel T. Differential Neural Responses Evoked by Orthonasal versus Retronasal Odorant Perception in Humans. Neuron 2005, 47: 593-605. PMID: 16102541, DOI: 10.1016/j.neuron.2005.07.022.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexCaudolateral orbitofrontal cortexRoute of deliveryInsula/operculumMedial orbitofrontal cortexPerigenual cingulateOral cavityCentral sulcusDifferential neural responsesRetronasal olfactionRetronasal routeBrain responsesNeural responsesNeural recruitmentDifferential activationPreferential activityCortexOdorant perceptionOrthonasalRetronasalDifferential neural recruitmentDeliveryResponseThalamusHippocampus