DRD2: Bridging the Genome and Ingestive Behavior
Sun X, Luquet S, Small DM. DRD2: Bridging the Genome and Ingestive Behavior. Trends In Cognitive Sciences 2017, 21: 372-384. PMID: 28372879, PMCID: PMC5745142, DOI: 10.1016/j.tics.2017.03.004.Peer-Reviewed Original ResearchConceptsGenetic variantsCommon gene variantsMetabolic dysfunctionNeurocognitive impairmentAppetitive functionsDA signalingCognitive declinePolygenic obesityBrain structures× environment interactionGene variantsConfer riskIngestive behaviorGene × environment interactionsNeurotransmitter dopamineObesityCognitive changesDopamineMetabolic signalsEnvironment interactionPivotal roleRiskSignalingFeedingDysfunction