2017
Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward
Veldhuizen MG, Babbs RK, Patel B, Fobbs W, Kroemer NB, Garcia E, Yeomans MR, Small DM. Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward. Current Biology 2017, 27: 2476-2485.e6. PMID: 28803868, PMCID: PMC5745144, DOI: 10.1016/j.cub.2017.07.018.Peer-Reviewed Original ResearchConceptsCaloric loadGreater metabolic responseNon-linear associationMetabolic responseSugar-sweetened beveragesBrain responsesLow-calorie beveragesHigh-calorie beveragesNon-nutritive sweetenersGreater brain responsePost-ingestive signalsHuman studiesSweet tasteNutrient metabolismCarbohydrate metabolismNovel mechanismBeveragesPotencyAssociationMetabolismCarbohydrate rewards
2016
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal
Sun X, Veldhuizen MG, Babbs AE, Sinha R, Small DM. Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal. Chemical Senses 2016, 41: 233-248. PMID: 26826114, PMCID: PMC4850930, DOI: 10.1093/chemse/bjv081.Peer-Reviewed Original ResearchConceptsBody mass indexMass indexHealthy weight subjectsBrain responsesFunctional magnetic resonance imagingMagnetic resonance imagingGhrelin suppressionWeight subjectsMetabolic healthFree fatty acidsMetabolic measuresAnimal studiesBody weightResonance imagingOlfactory-guided behaviorDifferential brain responsesEndocrine influencesChemosensory stimuliMetabolic peptidesMetabolic responseOlfactory sensitivityHuman researchInconsistent resultsMealFatty acids
2015
Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior
Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM. Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. NeuroImage 2015, 128: 273-283. PMID: 26724781, DOI: 10.1016/j.neuroimage.2015.12.031.Peer-Reviewed Original ResearchConceptsBrain responsesHigher body mass indexAd libitum food consumptionBody mass indexGreater weight lossNucleus Accumbens ResponseFunctional magnetic resonanceMilkshake receiptMass indexPlasma insulinPlasma glucoseMetabolic parametersDietary disinhibitionStriatal activityVariable response patternsWeight lossFood stimuliMetabolic responseSensory stimuliFood consumptionIntra-individual variationVariable responseMilkshakeMagnetic resonanceResponse patterns