2020
Identification of a brain fingerprint for overweight and obesity
Farruggia MC, van Kooten MJ, Perszyk EE, Burke MV, Scheinost D, Constable RT, Small DM. Identification of a brain fingerprint for overweight and obesity. Physiology & Behavior 2020, 222: 112940. PMID: 32417645, PMCID: PMC7321926, DOI: 10.1016/j.physbeh.2020.112940.Peer-Reviewed Original ResearchConceptsPercent body fatWaist circumferenceBody fatWhole-brain functional connectivityBrain network patternsGlucose toleranceBlood insulinObesityOverweightPathophysiological phenotypesFunctional connectivity networksFunctional connectivityMilkshake consumptionBrain correlatesBrain fingerprintsBMIAdiposityBrainCircumferenceConnectivity networksFatDiabetesPathophysiologyCentral roleInsulinShort-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism 2020, 31: 493-502.e7. PMID: 32130881, PMCID: PMC7784207, DOI: 10.1016/j.cmet.2020.01.014.Peer-Reviewed Original ResearchConceptsGlucose metabolismPrevalence of obesityType 2 diabetesSugar-sweetened beveragesConsumption of sucraloseHealthy human participantsInsulin sensitivityTerm consumptionTaste perceptionMetabolismLong-term decreaseSweet tasteMetabolic sensitivityComorbiditiesGeneral consensusObesityDiabetesHuman participantsBeveragesMidbrainPrevalenceBrainSimilar relationship
2018
Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia
Espeland M, Small D, Stoeckel L. Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia. 2018, 117-141. DOI: 10.1016/b978-0-12-809454-9.00007-x.Peer-Reviewed Original ResearchRisk factorsMetabolic dysfunctionModifiable risk factorsDevelopment of dementiaComplex multifactorial interactionPhysical inactivityCognitive dysfunctionNeurocognitive dysfunctionPhysical activityNeurocognitive impairmentObesityDysfunctionDiabetesDementiaMultifactorial interactionsDietFactorsImpairment
2017
Dopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective
Small DM. Dopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective. Frontiers In Neuroscience 2017, 11: 134. PMID: 28400713, PMCID: PMC5368264, DOI: 10.3389/fnins.2017.00134.Peer-Reviewed Original Research
2016
Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. PMID: 27303627, PMCID: PMC4897751, DOI: 10.12688/f1000research.8300.2.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaPatientsDigestiveImpairmentComplex mechanisms“White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction
Stoeckel L, Arvanitakis Z, Gandy S, Small D, Kahn C, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. “White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Research 2016, 5: 353. DOI: 10.12688/f1000research.8300.1.Peer-Reviewed Original ResearchNeurocognitive dysfunctionMetabolic dysfunctionImportant public health relevancePublic health relevanceVascular dementiaEpidemiologic evidenceInsulin resistanceKidney diseaseNeurocognitive impairmentDysfunctionAlzheimer's diseaseHealth relevanceDiabetesDiseaseScientific evidenceNational InstituteDementiaMeeting summaryPatientsDigestiveImpairmentComplex mechanisms