2018
Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain
Rosenbaum M, Agurs‐Collins T, Bray MS, Hall KD, Hopkins M, Laughlin M, MacLean PS, Maruvada P, Savage CR, Small DM, Stoeckel L. Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain. Obesity 2018, 26: s25-s34. PMID: 29575784, PMCID: PMC6945498, DOI: 10.1002/oby.22156.Peer-Reviewed Original ResearchConceptsObesity treatmentSurgical obesity treatmentAdult obesity treatmentTreatment responseBody compositionEnergy homeostasisObesity researchersBrain structuresObesity researchEvidence baseAccumulating DataWeight loss studiesTreatmentBiological measuresHigh-priority measuresIndividual variabilityKey biological factorsBiological factorsResponsePharmacologicalBiomarkersEnvironmental factorsAccumulation of data
2017
DRD2: Bridging the Genome and Ingestive Behavior
Sun X, Luquet S, Small DM. DRD2: Bridging the Genome and Ingestive Behavior. Trends In Cognitive Sciences 2017, 21: 372-384. PMID: 28372879, PMCID: PMC5745142, DOI: 10.1016/j.tics.2017.03.004.Peer-Reviewed Original ResearchConceptsGenetic variantsCommon gene variantsMetabolic dysfunctionNeurocognitive impairmentAppetitive functionsDA signalingCognitive declinePolygenic obesityBrain structures× environment interactionGene variantsConfer riskIngestive behaviorGene × environment interactionsNeurotransmitter dopamineObesityCognitive changesDopamineMetabolic signalsEnvironment interactionPivotal roleRiskSignalingFeedingDysfunction