2006
Proteome analysis of mitochondrial outer membrane from Neurospora crassa
Schmitt S, Prokisch H, Schlunck T, Camp DG, Ahting U, Waizenegger T, Scharfe C, Meitinger T, Imhof A, Neupert W, Oefner PJ, Rapaport D. Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Proteomics 2006, 6: 72-80. PMID: 16294304, DOI: 10.1002/pmic.200402084.Peer-Reviewed Original ResearchConceptsMitochondrial outer membraneOuter membraneOuter membrane vesiclesNeurospora crassaImport machineryEukaryotic cellsGenetic systemOMV proteinsBiosynthetic pathwayProteomic studiesNovel functionProteome analysisIntracellular locationMembrane vesiclesTryptic peptide digestsProteinCrassaNumerous interactionsGel electrophoresisPeptide digestsLC-MS/MSMembraneProteomeOrganellesMitochondria
2002
Systematic screen for human disease genes in yeast
Steinmetz LM, Scharfe C, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Systematic screen for human disease genes in yeast. Nature Genetics 2002, 31: 400-404. PMID: 12134146, DOI: 10.1038/ng929.Peer-Reviewed Original ResearchConceptsMitochondrial proteinsNuclear-encoded mitochondrial proteinsGenomic map positionFunctional genomic studiesHuman disease genesGene expression analysisHuman mitochondriaYeast deletionHuman orthologGenomic studiesMap positionHuman genesSystematic screenFunctional screenStrain fitnessExpression analysisDisease genesHuman disordersMitochondrial diseaseHigh similarityMitochondrial respirationHeritable diseaseMitochondrial functionGenesProtein