2006
The Role of Selection in the Evolution of Human Mitochondrial Genomes
Kivisild T, Shen P, Wall DP, Do B, Sung R, Davis K, Passarino G, Underhill PA, Scharfe C, Torroni A, Scozzari R, Modiano D, Coppa A, de Knijff P, Feldman M, Cavalli-Sforza LL, Oefner PJ. The Role of Selection in the Evolution of Human Mitochondrial Genomes. Genetics 2006, 172: 373-387. PMID: 16172508, PMCID: PMC1456165, DOI: 10.1534/genetics.105.043901.Peer-Reviewed Original ResearchConceptsHuman mitochondrial genomeMitochondrial genomeNegative Tajima's D valuesMutation rateHeavy strand DNAMammalian mitochondrial DNATajima's D valuesRole of selectionAmino acid replacementsNonsynonymous base substitutionsHigh mutation rateSynonymous sitesPhylogenetic treeMitochondrial DNAPhylogenetic analysisCodon usageCoalescent timesCold adaptationNonsynonymous changesAcid replacementsSynonymous transitionsDivergent poolValine codonNonsynonymous mutationsBase substitutions
2003
Role of duplicate genes in genetic robustness against null mutations
Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH. Role of duplicate genes in genetic robustness against null mutations. Nature 2003, 421: 63-66. PMID: 12511954, DOI: 10.1038/nature01198.Peer-Reviewed Original ResearchConceptsDuplicate genesGenetic robustnessNull mutationSevere fitness effectsGenome-wide evaluationAlternative metabolic pathwaysFitness effectsLoss of functionSequence similarityRegulatory networksDeletion mutantsS. cerevisiaeGenesMetabolic pathwaysDuplicate copiesGene deletionFunctional compensationFitness dataCopiesMutationsMutantsCerevisiaeRelative importanceOrganismsSecond mechanism
2002
Evolutionary Rate in the Protein Interaction Network
Fraser HB, Hirsh AE, Steinmetz LM, Scharfe C, Feldman MW. Evolutionary Rate in the Protein Interaction Network. Science 2002, 296: 750-752. PMID: 11976460, DOI: 10.1126/science.1068696.Peer-Reviewed Original ResearchConceptsProtein interaction networksInteraction networksMost cellular functionsRate of evolutionHigh-throughput screenMolecular evolutionEvolutionary ratesYeast SaccharomycesCellular functionsEvolutionary changeSelection pressureProtein resultsProteinMore interactorsInteractorsFundamental questionsSaccharomycesCoevolutionEvolutionOrganismsReciprocal changesFunctionSimilar ratesGreater proportionScreen