2008
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.Peer-Reviewed Original ResearchConceptsSpine synapse formationNonhuman primate modelSynapse formationPrimate modelAbility of BPAPrefrontal cortexOvariectomized nonhuman primatesLimbic brain areasHuman BPA exposureRodent animal modelsLow exposure levelsBPA administrationDaily doseMale ratsSpine synapsesBPA exposureAnimal modelsBrain areasSynthetic xenoestrogenCognitive functionNonhuman primatesAdverse effectsExposure levelsPolycarbonate plasticsExposure measurements
2007
Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats
Hajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C. Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats. Endocrinology 2007, 148: 1963-1967. PMID: 17317772, PMCID: PMC2128740, DOI: 10.1210/en.2006-1626.Peer-Reviewed Original ResearchConceptsSpine synapse formationMale ratsWild-type animalsPrefrontal cortexTfm ratsSpine synapsesAndrogen receptorSynapse formationEffects of androgensSynaptogenic actionsTfm malesGonadal steroidsSynaptogenic effectsGonadal hormonesSynaptic remodelingTfm animalsFemale monkeysRatsCortexCortical spinesCognitive effectsAndrogensReceptorsSynapsesAdult males
2006
Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors
MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 2006, 147: 2392-2398. PMID: 16439462, DOI: 10.1210/en.2005-0673.Peer-Reviewed Original ResearchConceptsDefective androgen receptorHippocampal synaptic responsesEstradiol benzoateAndrogen receptorMale ratsSpine synapsesTfm malesSynaptic responsesAndrogen effectsTfm mutationEffects of EBDose of EBHippocampal CA1 synapsesSpine synapse numberSesame oil vehicleDendritic spine synapsesCA1 stratum radiatumAdult male ratsHippocampal spine synapsesVehicle-injected controlsHormone-induced increaseAgonists/antagonistsWild-type animalsWild-type malesCA1 synapses
2005
The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
MacLusky NJ, Hajszan T, Leranth C. The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis. Environmental Health Perspectives 2005, 113: 675-679. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.Peer-Reviewed Original ResearchConceptsEnvironmental BPA exposureHippocampal synapse formationDendritic spine synapsesEndogenous estrogen productionHuman exposureNormal sex differencesHippocampus-dependent memoryHippocampal synaptogenesisOvariectomized ratsPyramidal neuronsBPA doseCA1 areaEstrogen productionSpine synapsesBPA exposureSignificant inhibitory effectSynaptic remodelingHippocampal functionSynapse formationCognitive functionNormal agingRapid effectsInhibitory effectManufacture of plasticsDental prostheses