2008
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.Peer-Reviewed Original ResearchConceptsSpine synapse formationNonhuman primate modelSynapse formationPrimate modelAbility of BPAPrefrontal cortexOvariectomized nonhuman primatesLimbic brain areasHuman BPA exposureRodent animal modelsLow exposure levelsBPA administrationDaily doseMale ratsSpine synapsesBPA exposureAnimal modelsBrain areasSynthetic xenoestrogenCognitive functionNonhuman primatesAdverse effectsExposure levelsPolycarbonate plasticsExposure measurements
2007
Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats
Hajszan T, MacLusky NJ, Johansen JA, Jordan CL, Leranth C. Effects of Androgens and Estradiol on Spine Synapse Formation in the Prefrontal Cortex of Normal and Testicular Feminization Mutant Male Rats. Endocrinology 2007, 148: 1963-1967. PMID: 17317772, PMCID: PMC2128740, DOI: 10.1210/en.2006-1626.Peer-Reviewed Original ResearchConceptsSpine synapse formationMale ratsWild-type animalsPrefrontal cortexTfm ratsSpine synapsesAndrogen receptorSynapse formationEffects of androgensSynaptogenic actionsTfm malesGonadal steroidsSynaptogenic effectsGonadal hormonesSynaptic remodelingTfm animalsFemale monkeysRatsCortexCortical spinesCognitive effectsAndrogensReceptorsSynapsesAdult males