2006
Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors
MacLusky NJ, Hajszan T, Johansen JA, Jordan CL, Leranth C. Androgen Effects on Hippocampal CA1 Spine Synapse Numbers Are Retained in Tfm Male Rats with Defective Androgen Receptors. Endocrinology 2006, 147: 2392-2398. PMID: 16439462, DOI: 10.1210/en.2005-0673.Peer-Reviewed Original ResearchConceptsDefective androgen receptorHippocampal synaptic responsesEstradiol benzoateAndrogen receptorMale ratsSpine synapsesTfm malesSynaptic responsesAndrogen effectsTfm mutationEffects of EBDose of EBHippocampal CA1 synapsesSpine synapse numberSesame oil vehicleDendritic spine synapsesCA1 stratum radiatumAdult male ratsHippocampal spine synapsesVehicle-injected controlsHormone-induced increaseAgonists/antagonistsWild-type animalsWild-type malesCA1 synapses
2005
The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
MacLusky NJ, Hajszan T, Leranth C. The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis. Environmental Health Perspectives 2005, 113: 675-679. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.Peer-Reviewed Original ResearchConceptsEnvironmental BPA exposureHippocampal synapse formationDendritic spine synapsesEndogenous estrogen productionHuman exposureNormal sex differencesHippocampus-dependent memoryHippocampal synaptogenesisOvariectomized ratsPyramidal neuronsBPA doseCA1 areaEstrogen productionSpine synapsesBPA exposureSignificant inhibitory effectSynaptic remodelingHippocampal functionSynapse formationCognitive functionNormal agingRapid effectsInhibitory effectManufacture of plasticsDental prostheses