Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques
Rhoades N, Davies M, Lewis S, Cinco I, Kohama S, Bermudez L, Winthrop K, Fuss C, Mattison J, Spindel E, Messaoudi I. Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques. Cell Reports 2022, 39: 110725. PMID: 35443183, PMCID: PMC9096119, DOI: 10.1016/j.celrep.2022.110725.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsCD8-Positive T-LymphocytesCross-Sectional StudiesFemaleLungMacaca mulattaMaleConceptsT cellsCD8<sup>+</sup> T cellsCD8<sup>+</sup> TRhesus macaque modelPulmonary function testsSevere respiratory infectionsSeverity of respiratory diseasePulmonary ageCross-sectional studyMacaque modelInfiltrating macrophagesImmunological landscapeRespiratory infectionsImpact of ageComprehensive cross-sectional studyIncreased riskAge-related changesFunction testsAged animalsIncreased prevalenceHealthy humansRespiratory tractRhesus macaquesConsequence of agingLung