2013
Heat‐shock–mediated conditional regulation of hedgehog/gli signaling in zebrafish
Shen M, Ozacar A, Osgood M, Boeras C, Pink J, Thomas J, Kohtz J, Karlstrom R. Heat‐shock–mediated conditional regulation of hedgehog/gli signaling in zebrafish. Developmental Dynamics 2013, 242: 539-549. PMID: 23441066, DOI: 10.1002/dvdy.23955.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHeat-Shock ResponseHedgehog ProteinsHSP70 Heat-Shock ProteinsOncogene ProteinsPromoter Regions, GeneticSignal TransductionTrans-ActivatorsZebrafishZebrafish ProteinsZinc Finger Protein GLI1ConceptsTransgenic linesConditional regulationHeat shockEmbryonic central nervous systemZebrafish transgenic linesNew reporter linesHeat shock activationInducible transgenic linesHedgehog/GLIStem cell proliferationSingle heat shockHh responseHh functionFunction phenotypesPostembryonic rolesReporter linesPromoter elementsHedgehog signalingJuvenile stageSitu hybridizationCell proliferationEarly embryonic lossQuantitative polymerase chain reactionLife cycleNew experimental tools
2011
Uric Acid Induces Trophoblast IL‐1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia
Mulla MJ, Myrtolli K, Potter J, Boeras C, Kavathas PB, Sfakianaki AK, Tadesse S, Norwitz ER, Guller S, Abrahams VM. Uric Acid Induces Trophoblast IL‐1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia. American Journal Of Reproductive Immunology 2011, 65: 542-548. PMID: 21352397, PMCID: PMC3114103, DOI: 10.1111/j.1600-0897.2010.00960.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1Cell LineCytoskeletal ProteinsDisease ProgressionEnzyme ActivationFemaleGene Expression Regulation, DevelopmentalHumansHyperuricemiaInflammasomesInterleukin-1betaMaternal-Fetal RelationsNLR Family, Pyrin Domain-Containing 3 ProteinNLR ProteinsPre-EclampsiaPregnancyTrophoblastsUric AcidConceptsIL-1β secretionIL-1β productionMonosodium urateTrophoblast cellsUric acidFirst trimester trophoblast cellsAdverse pregnancy outcomesPathogenesis of preeclampsiaMaternal-fetal interfaceInduction of inflammationActive IL-1βNOD-like receptorsThird trimester trophoblastActive caspase-1Uric acid increasesCaspase-1 activationIL-1β processingPregnancy outcomesInflammatory dysregulationPlacental dysfunctionClinical manifestationsIL-1βInflammasome activationNALP3 inflammasomePreeclampsia