Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus
Rojas-Rodriguez R, Lifshitz L, Bellve K, Min S, Pires J, Leung K, Boeras C, Sert A, Draper J, Corvera S, Moore Simas T. Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus. Diabetologia 2015, 58: 2106-2114. PMID: 26067361, PMCID: PMC4526585, DOI: 10.1007/s00125-015-3662-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAdipose TissueAdiposityAdultBlood GlucoseCapillariesCross-Sectional StudiesDiabetes, GestationalFemaleGene Expression ProfilingGene Expression RegulationGlucose Tolerance TestHumansInsulin-Like Growth Factor Binding Protein 5Insulin-Like Growth Factor IInsulin-Like Growth Factor IINeovascularization, PhysiologicOligonucleotide Array Sequence AnalysisPregnancyReal-Time Polymerase Chain ReactionConceptsGestational diabetes mellitusNormal glucose toleranceDiabetes mellitusCapillary densityAdipocyte sizeType 2 diabetes mellitusMethodsThis cross-sectional studyCapillary growthEctopic lipid depositionIGF binding proteinNon-pregnant womenCross-sectional studyAdipose tissue expansionCaesarean deliveryGlucose tolerancePregnant womenInsulin resistanceAdipocyte hypertrophyAT expansionQuantitative real-time PCRReal-time PCRIGF-1Real-time PCR studiesAims/Lipid deposition