2006
Genetics of Mouse Macrophage Resistance to Legionella pneumophila
Vance R, Ren T, Zamboni D, Roy C, Dietrich W. Genetics of Mouse Macrophage Resistance to Legionella pneumophila. 2006, 301-306. DOI: 10.1128/9781555815660.ch73.Peer-Reviewed Original ResearchB6 macrophagesRapid cell deathMacrophage resistanceBacterial geneticsProtein kinaseNod proteinsLegionella replicationGenetic studiesPutative ligandCell deathProtein 5Intracellular receptorsGeneticsMouse macrophagesLegionella pneumophilaBiological relationshipsPowerful approachFlagellinJ macrophagesNAIPLegionella growthKnockout miceConcerted applicationMacrophagesImmune system
1998
Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake
Roy C, Berger K, Isberg R. Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake. Molecular Microbiology 1998, 28: 663-674. PMID: 9632267, DOI: 10.1046/j.1365-2958.1998.00841.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDBacterial ProteinsCell LineFluorescent Antibody TechniqueGTP-Binding ProteinsHumansLegionella pneumophilaLysosome-Associated Membrane GlycoproteinsLysosomesMacrophagesMembrane FusionMembrane GlycoproteinsMembrane ProteinsMiceMutationPhagosomesPlasmidsRab GTP-Binding ProteinsRab7 GTP-Binding ProteinsConceptsDotA mutantsL. pneumophila phagosomeLAMP-1DotA proteinL. pneumophilaMembrane-bound compartmentsLysosomal glycoprotein LAMP-1Bacterial pathogensIntracellular bacterial pathogenReplicative phagosomeSmall GTPVacuolar membraneEndocytic pathwayProtein Rab7Fusion eventsMutant bacteriaMolecular basisGenetic studiesBacterial uptakeMutantsPhagosomesTrafficking profilesContinuous expressionIntracellular sitesMacrophage uptake