Featured Publications
Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila
Case CL, Shin S, Roy CR. Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila. Infection And Immunity 2009, 77: 1981-1991. PMID: 19237518, PMCID: PMC2681768, DOI: 10.1128/iai.01382-08.Peer-Reviewed Original ResearchConceptsCaspase-1 activationL. pneumophilaWild-type L. pneumophilaCaspase-1-mediated processingDifferent adapter proteins
2006
NALP3: a key player in caspase-1 activation
Sutterwala F, Ogura Y, Zamboni D, Roy C, Flavell R. NALP3: a key player in caspase-1 activation. Innate Immunity 2006, 12: 251-256. PMID: 16953978, DOI: 10.1177/09680519060120040701.Peer-Reviewed Original ResearchConceptsNLR familyCell death pathwaysNLR family membersAdaptor molecule ASCPro-inflammatory caspasesMultiprotein complexesDeath pathwaysPathogen recognitionCaspase-1 activationKey playersRecent findingsCaspase-1Family membersAuto-inflammatory syndromeActivationAuto-inflammatory disordersFamilyCaspasesGenesMuckle-Wells syndromeBiologyImmune responseProteinMembersFamilial cold auto-inflammatory syndrome