1995
Mek MAPK/Erk kinase (vertebrates) (MAP kinase kinase, MAPKK)
Erikson R, Alessandrini A, Crews C. Mek MAPK/Erk kinase (vertebrates) (MAP kinase kinase, MAPKK). 1995, 275-277. DOI: 10.1016/b978-012324719-3/50085-6.Peer-Reviewed Original ResearchMAPK/ERK kinaseMAP kinaseERK kinaseReversible protein phosphorylationAmino acid sequenceRelated gene productsMEK1/MEK2Microtubule-associated proteinsOutside vertebratesPhosphorylation eventsERK2 geneProtein phosphorylationKinase domainRaf-1MEK kinaseGene productsAcid sequenceTyrosine residuesFusion proteinKinaseMouse tissuesExogenous substratesByr1MEKProtein
1992
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.
Crews CM, Erikson RL. Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 8205-8209. PMID: 1381507, PMCID: PMC49886, DOI: 10.1073/pnas.89.17.8205.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsEnzyme ActivationFungal ProteinsGenesMiceMitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesMolecular Sequence DataPeptide FragmentsPhosphorylationPhosphoserinePhosphothreoninePhosphotyrosineProtein KinasesRecombinant ProteinsSequence AlignmentTyrosineConceptsGene productsProtein kinaseSerine/threonine phosphatase 2AMyelin basic protein kinaseProtein tyrosine phosphatase 1B.MAPK/ERK kinaseSignal transduction mechanismsPossible signal transduction mechanismsERK-1 proteinSte7 genePhosphatase 2AThreonine kinaseERK kinaseERK-1Tyrosine residuesSequence analysisKinaseTransduction mechanismsMEKTrypsin digestionProteinByr1PurificationGenesLesser extent