2023
Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2019
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients
Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAge FactorsAgedAged, 80 and overAgingAnimalsAntioxidantsApoptosisBiomarkersBlood PlateletsCardiovascular DiseasesComorbidityDisease Models, AnimalFemaleHomeostasisHumansMaleMiceMiddle AgedOxidation-ReductionOxidative StressPlatelet ActivationPlatelet AdhesivenessReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsRisk patientsMouse studiesPlatelet phenotypeMajor adverse cardiovascular eventsHigh cardiovascular risk patientsAdaptive increaseAdverse cardiovascular eventsCentral pathophysiological roleCVD risk patientsCardiovascular risk patientsAggressive antiplatelet therapyEffect of comorbidityAge group 40Young healthy subjectsAntiplatelet therapyCardiovascular eventsYear age cohortAdvanced ageCVD patientsGroup 40Healthy subjectsPathophysiological roleElderly populationCardiovascular pathologyPatients
2014
Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study).
Ionescu CN, Chrissoheris MP, Slim HB, Slade M, Oen-Hsiao J, Donohue TJ, Bekui A, Ghantous AE. Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study). Connecticut Medicine 2014, 78: 133-8. PMID: 24772828.Peer-Reviewed Original ResearchConceptsHigh-sensitivity C-reactive proteinC-reactive proteinAcute myocardial infarctionEmergency departmentCause rehospitalizationChest painMyocardial infarctionChest pain evaluationCoronary revascularizationHs-CRPConsecutive patientsFinal cohortPain evaluationMyocardial ischemiaClinical valuePatientsRehospitalizationPainInfarctionDepartmentDaysRevascularizationIschemiaCohortCRP
2010
Long-term Outcome of Tako-tsubo Cardiomyopathy
Ionescu CN, Aguilar-Lopez CA, Sakr AE, Ghantous AE, Donohue TJ. Long-term Outcome of Tako-tsubo Cardiomyopathy. Heart Lung And Circulation 2010, 19: 601-605. PMID: 20655278, DOI: 10.1016/j.hlc.2010.06.667.Peer-Reviewed Original ResearchConceptsTako-tsubo cardiomyopathyLong-term outcomesMyocardial Infarction (TIMI) myocardial perfusion gradeCombined end pointMyocardial perfusion gradeLeft heart catheterisationSudden cardiac deathCardiac reasonsCardiogenic shockHeart catheterisationCardiac deathPerfusion gradeMean agePrognostic implicationsExcellent outcomesRetrospective analysisCaucasian femalePatientsEnd pointOutcomesFive-year periodCardiomyopathyTMPGStressor eventsCurrent data