2021
Examining a brief measure and observed cutoff scores to identify reward and relief drinking profiles: Psychometric properties and pharmacotherapy response
Votaw VR, Mann K, Kranzler HR, Roos CR, Nakovics H, Witkiewitz K. Examining a brief measure and observed cutoff scores to identify reward and relief drinking profiles: Psychometric properties and pharmacotherapy response. Drug And Alcohol Dependence 2021, 232: 109257. PMID: 35042096, PMCID: PMC8885897, DOI: 10.1016/j.drugalcdep.2021.109257.Peer-Reviewed Original ResearchMeSH KeywordsAcamprosateAlcohol DeterrentsAlcohol DrinkingAlcoholismFemaleHumansMaleNaltrexonePsychometricsRewardConceptsBrief measureCutoff scorePharmacotherapy responseAlcohol dependence severityItem response theoryGood construct validityNegative statesLatent profilesDrinking situationsDisorder outcomesDependence severityDifferential itemPsychometric propertiesDrinking subgroupDrinking measuresConstruct validityPositive experiencesHeavy drinkingRewardResponse theoryAUD medicationsDrinking profilesNaltrexone treatment responseDrinkingMeasuresWithin-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes
Maisto SA, Hallgren KA, Swan JE, Roos C, Witkiewitz K. Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes. Drug And Alcohol Dependence 2021, 228: 108968. PMID: 34560333, PMCID: PMC11170462, DOI: 10.1016/j.drugalcdep.2021.108968.Peer-Reviewed Original ResearchConceptsLong-term outcomesReward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original ResearchA Bridge to Nowhere: Resistance to the Possibility of Some Heavy Drinking During Recovery and the Potential Public Health Implications
Witkiewitz K, Wilson AD, Pearson MR, Roos CR, Swan JE, Votaw VR, Stein ER, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. A Bridge to Nowhere: Resistance to the Possibility of Some Heavy Drinking During Recovery and the Potential Public Health Implications. Journal Of Addiction Medicine 2021, 15: 352-353. PMID: 33577228, PMCID: PMC8352995, DOI: 10.1097/adm.0000000000000796.Peer-Reviewed Original Research
2020
Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes
Maisto SA, Hallgren KA, Roos CR, Swan JE, Witkiewitz K. Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes. Journal Of Consulting And Clinical Psychology 2020, 88: 1119-1132. PMID: 33370135, PMCID: PMC7900838, DOI: 10.1037/ccp0000615.Peer-Reviewed Original ResearchConceptsLong-term outcomesHeavy drinkingBetter long-term outcomesAlcohol use disorder treatmentRemission/relapsePattern of remissionOutpatient alcohol treatmentUse disorder treatmentFirst yearContinuous relapseContinuous remissionMore relapsesClinical courseOutpatient treatmentRemissionDrinking statusLong-term recoveryRelapsePosttreatment periodDisorder treatmentAlcohol treatmentRelapse episodesAverage durationFunctioning outcomesHeavy drinking statusCan Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment
Witkiewitz K, Wilson AD, Roos CR, Swan JE, Votaw VR, Stein ER, Pearson MR, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. Can Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment. Journal Of Addiction Medicine 2020, 15: 303-310. PMID: 33060466, PMCID: PMC8044251, DOI: 10.1097/adm.0000000000000760.Peer-Reviewed Original Research
2019
Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinkingMindfulness‐Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double‐Blind Sham‐Controlled Randomized Trial
Witkiewitz K, Stein ER, Votaw VR, Wilson AD, Roos CR, Gallegos SJ, Clark VP, Claus ED. Mindfulness‐Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double‐Blind Sham‐Controlled Randomized Trial. Alcohol Clinical And Experimental Research 2019, 43: 1296-1307. PMID: 30977904, PMCID: PMC6551269, DOI: 10.1111/acer.14053.Peer-Reviewed Original ResearchConceptsMindfulness-based relapse preventionAlcohol cue reactivityAlcohol use disorderDirect current stimulationCue reactivitySham-controlled randomized trialHeavy drinking daysStop-signal reaction time taskRelapse preventionCurrent stimulationRight inferior frontal gyrusSelf-reported cravingInferior frontal gyrusReaction time taskTranscranial direct current stimulationPercent heavy drinking daysDrinking daysCurrent studyCue taskResponse inhibitionTime taskFrontal gyrusNeurobiological dysfunctionAnodal tDCSGroup treatment
2018
Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment
Witkiewitz K, Kirouac M, Roos CR, Wilson AD, Hallgren KA, Bravo AJ, Montes KS, Maisto SA. Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment. Psychology Of Addictive Behaviors 2018, 32: 639-646. PMID: 30160499, PMCID: PMC6136973, DOI: 10.1037/adb0000381.Peer-Reviewed Original ResearchConceptsLow-risk drinkingRisk drinkingHeavy drinkingDrinking daysAlcohol-related consequencesAlcohol usePersistent heavy drinkingWeeks of treatmentOutcomes 3 yearsDrinking outcomesHeavy drinking daysLow-risk drinkersAlcohol use disorderMeasures latent class analysisOutpatient armRisk drinkersOutcome measuresHeavy drinking episodesLower riskUse disordersHeavy drinkersFunctioning outcomesPsychosocial functioningAbstinenceDrinking episodesProfiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers?
Witkiewitz K, Wilson AD, Pearson MR, Montes KS, Kirouac M, Roos CR, Hallgren KA, Maisto SA. Profiles of recovery from alcohol use disorder at three years following treatment: can the definition of recovery be extended to include high functioning heavy drinkers? Addiction 2018, 114: 69-80. PMID: 30063267, PMCID: PMC6289769, DOI: 10.1111/add.14403.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol AbstinenceAlcoholics AnonymousAlcoholismCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansLatent Class AnalysisMaleMental HealthMental Health RecoveryMiddle AgedMotivational InterviewingPersonal SatisfactionSocial BehaviorTreatment OutcomeUnemploymentConceptsOccasional heavy drinkersAlcohol use disorderHeavy drinkersNon-heavy drinkersUse disordersPsychosocial functioningSecondary analysisMental healthInfrequent heavy drinkersTreatment-related variablesRandomized clinical trialsAlcoholics Anonymous (AA) involvementFrequent heavy drinkersPost-treatment abstinenceProfiles of recoveryClinical trialsDefinition of recoveryAlcohol-related problemsAlcohol dependence severityDrug useAlcohol useRecovery outcomesHeavy drinkingDrinkersDependence severityResponse to Letter to Editor (Precision medicine in alcohol dependence: evidence of efficacy and initial support for comparative effectiveness)
Mann K, Roos CR, Witkiewitz K. Response to Letter to Editor (Precision medicine in alcohol dependence: evidence of efficacy and initial support for comparative effectiveness). Neuropsychopharmacology 2018, 43: 1801-1802. PMID: 29930387, PMCID: PMC6046056, DOI: 10.1038/s41386-018-0113-x.Peer-Reviewed Original ResearchCourse of remission from and relapse to heavy drinking following outpatient treatment of alcohol use disorder
Maisto SA, Hallgren KA, Roos CR, Witkiewitz K. Course of remission from and relapse to heavy drinking following outpatient treatment of alcohol use disorder. Drug And Alcohol Dependence 2018, 187: 319-326. PMID: 29705545, PMCID: PMC5959805, DOI: 10.1016/j.drugalcdep.2018.03.011.Peer-Reviewed Original ResearchBroad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation.
Witkiewitz K, Roos CR, Tofighi D, Van Horn ML. Broad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation. Journal Of Studies On Alcohol And Drugs 2018, 79: 199-207. PMID: 29553346, PMCID: PMC6019776, DOI: 10.15288/jsad.2018.79.199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderMedication managementBehavioral interventionsDrinking outcomesOutcomes 12 monthsCombined Behavioral InterventionCombined PharmacotherapiesUse disordersAUD treatmentCoping repertoireCOMBINE StudySecondary analysisSignificant mediatorAlcohol Dependence (COMBINE) StudyBehavioral treatmentIntervention efficacyBroad coping repertoireMultisite studyInterventionGreater likelihoodOutcomesTreatmentMediatorsAlcohol outcomesBehavior change
2017
Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes
Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, Heinz A, Witkiewitz K. Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes. Neuropsychopharmacology 2017, 43: 891-899. PMID: 29154368, PMCID: PMC5809801, DOI: 10.1038/npp.2017.282.Peer-Reviewed Original ResearchConceptsBetter treatment responseAlcohol dependenceTreatment responsePREDICT studyAnalysis of subgroupsSubgroup of individualsRelief scoresActive medicationRandomized trialsAD patientsSelf-report questionnairesMedicationsNaltrexonePharmacotherapy responseHigher effect sizesHeavy drinkingClinical applicabilityCutoff analysisDrinking phenotypesPlaceboPrecision medicineDrinkersPatientsEffect sizeDrinkingWho achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials
Witkiewitz K, Pearson MR, Hallgren KA, Maisto SA, Roos CR, Kirouac M, Wilson AD, Montes KS, Heather N. Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials. Addiction 2017, 112: 2112-2121. PMID: 28511286, PMCID: PMC5673549, DOI: 10.1111/add.13870.Peer-Reviewed Original ResearchConceptsLow-risk drinkingPatterns of drinkingHeavy drinkingAlcohol dependenceSelf-reported weekly alcohol consumptionDrinking patternsPersistent heavy drinkingRepeated-measures latent class analysisWeekly alcohol consumptionAlcohol clinical trialsBehavioral intervention studyAlcohol Treatment TrialUnited Kingdom Alcohol Treatment TrialTreatment trialsCombined PharmacotherapiesClinical trialsAverage ageAlcohol consumptionAlcohol dependence severityIntervention studiesAlcohol treatmentCollateral informantsForm 90Dependence severityLatent class analysisCoping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high
Roos CR, Maisto SA, Witkiewitz K. Coping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high. Addiction 2017, 112: 1547-1557. PMID: 28388836, PMCID: PMC5544539, DOI: 10.1111/add.13841.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTwelve-step facilitationCognitive behavioral therapyMotivational enhancement therapyUse disordersPositive treatment effectDependence severityDrinking outcomesTreatment effectsProject MATCHPercentage days abstinentHeavy drinking daysAlcohol Treatment TrialPrimary outcomeTreatment armsTreatment trialsSecondary data analysisDays abstinentDrinking daysAlcohol Dependence ScaleTherapyPatient samplesEnhancement therapySeverityChange QuestionnaireHow Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials.
Witkiewitz K, Roos CR, Pearson MR, Hallgren KA, Maisto SA, Kirouac M, Forcehimes AA, Wilson AD, Robinson CS, McCallion E, Tonigan JS, Heather N. How Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials. Journal Of Studies On Alcohol And Drugs 2017, 78: 59-69. PMID: 27936365, PMCID: PMC5148751, DOI: 10.15288/jsad.2017.78.59.Peer-Reviewed Original ResearchConceptsBetter long-term outcomesLong-term outcomesPersistent heavy drinkingLow-risk drinkingPatterns of drinkingHeavy drinkingClinical trialsAlcohol treatmentWorse long-term outcomesDrinking patternsWeeks of treatmentRandomized clinical trialsNon-heavy drinkingRepeated-measures latent class analysisLow-risk drinkersAlcohol use disorderPost-treatment outcomesAlcohol clinical trialsAlcohol Treatment TrialNegative long-term outcomesTreatment trialsWorse outcomesSecondary data analysisUse disordersPatients
2016
Do Alcohol Relapse Episodes During Treatment Predict Long‐Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse
Maisto SA, Roos CR, Hallgren KA, Moskal D, Wilson AD, Witkiewitz K. Do Alcohol Relapse Episodes During Treatment Predict Long‐Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse. Alcohol Clinical And Experimental Research 2016, 40: 2180-2189. PMID: 27591560, PMCID: PMC5048537, DOI: 10.1111/acer.13173.Peer-Reviewed Original ResearchConceptsWomen/menRelapse definitionAlcohol consumptionLong-term alcohol-related outcomesAlcohol use disorder treatmentEnd of treatmentLong-term outcomesUse disorder treatmentDisorder relapseSingle drinking episodeYear posttreatmentRelapseDisorder treatmentAlcohol-related consequencesAlcohol-related outcomesBest predictorRelapse episodesSecondary analysisClinical researchPsychosocial functioningAUD researchDrinking episodesOutcomesMenProject MATCHReward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone
Roos CR, Mann K, Witkiewitz K. Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone. Addiction Biology 2016, 22: 1528-1539. PMID: 27480445, PMCID: PMC5290305, DOI: 10.1111/adb.12427.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment of AUDOpioid receptor antagonistRandomized clinical trialsBetter drinking outcomesGlutamatergic systemSubtypes of individualsReceptor antagonistClinical trialsRewarding effectsUse disordersClinical decisionDrinking outcomesReward drinkersDrinkersNaltrexoneExcellent reliabilityDifferential benefitsDistinct patterns
2015
Reproducibility and differential item functioning of the alcohol dependence syndrome construct across four alcohol treatment studies: An integrative data analysis
Witkiewitz K, Hallgren KA, O'Sickey AJ, Roos CR, Maisto SA. Reproducibility and differential item functioning of the alcohol dependence syndrome construct across four alcohol treatment studies: An integrative data analysis. Drug And Alcohol Dependence 2015, 158: 86-93. PMID: 26613839, PMCID: PMC4698096, DOI: 10.1016/j.drugalcdep.2015.11.001.Peer-Reviewed Original Research