2021
Examining a brief measure and observed cutoff scores to identify reward and relief drinking profiles: Psychometric properties and pharmacotherapy response
Votaw VR, Mann K, Kranzler HR, Roos CR, Nakovics H, Witkiewitz K. Examining a brief measure and observed cutoff scores to identify reward and relief drinking profiles: Psychometric properties and pharmacotherapy response. Drug And Alcohol Dependence 2021, 232: 109257. PMID: 35042096, PMCID: PMC8885897, DOI: 10.1016/j.drugalcdep.2021.109257.Peer-Reviewed Original ResearchMeSH KeywordsAcamprosateAlcohol DeterrentsAlcohol DrinkingAlcoholismFemaleHumansMaleNaltrexonePsychometricsRewardConceptsBrief measureCutoff scorePharmacotherapy responseAlcohol dependence severityItem response theoryGood construct validityNegative statesLatent profilesDrinking situationsDisorder outcomesDependence severityDifferential itemPsychometric propertiesDrinking subgroupDrinking measuresConstruct validityPositive experiencesHeavy drinkingRewardResponse theoryAUD medicationsDrinking profilesNaltrexone treatment responseDrinkingMeasuresWithin-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes
Maisto SA, Hallgren KA, Swan JE, Roos C, Witkiewitz K. Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes. Drug And Alcohol Dependence 2021, 228: 108968. PMID: 34560333, PMCID: PMC11170462, DOI: 10.1016/j.drugalcdep.2021.108968.Peer-Reviewed Original ResearchConceptsLong-term outcomesReward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcohol DrinkingAlcoholismBlood Alcohol ContentFemaleHumansMaleNaltrexoneRewardYoung AdultA Bridge to Nowhere: Resistance to the Possibility of Some Heavy Drinking During Recovery and the Potential Public Health Implications
Witkiewitz K, Wilson AD, Pearson MR, Roos CR, Swan JE, Votaw VR, Stein ER, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. A Bridge to Nowhere: Resistance to the Possibility of Some Heavy Drinking During Recovery and the Potential Public Health Implications. Journal Of Addiction Medicine 2021, 15: 352-353. PMID: 33577228, PMCID: PMC8352995, DOI: 10.1097/adm.0000000000000796.Peer-Reviewed Original Research
2020
Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes
Maisto SA, Hallgren KA, Roos CR, Swan JE, Witkiewitz K. Patterns of Transitions Between Relapse to and Remission From Heavy Drinking Over the First Year After Outpatient Alcohol Treatment and Their Relation to Long-Term Outcomes. Journal Of Consulting And Clinical Psychology 2020, 88: 1119-1132. PMID: 33370135, PMCID: PMC7900838, DOI: 10.1037/ccp0000615.Peer-Reviewed Original ResearchConceptsLong-term outcomesHeavy drinkingBetter long-term outcomesAlcohol use disorder treatmentRemission/relapsePattern of remissionOutpatient alcohol treatmentUse disorder treatmentFirst yearContinuous relapseContinuous remissionMore relapsesClinical courseOutpatient treatmentRemissionDrinking statusLong-term recoveryRelapsePosttreatment periodDisorder treatmentAlcohol treatmentRelapse episodesAverage durationFunctioning outcomesHeavy drinking statusCan Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment
Witkiewitz K, Wilson AD, Roos CR, Swan JE, Votaw VR, Stein ER, Pearson MR, Edwards KA, Tonigan JS, Hallgren KA, Montes KS, Maisto SA, Tucker JA. Can Individuals With Alcohol Use Disorder Sustain Non-abstinent Recovery? Non-abstinent Outcomes 10 Years After Alcohol Use Disorder Treatment. Journal Of Addiction Medicine 2020, 15: 303-310. PMID: 33060466, PMCID: PMC8044251, DOI: 10.1097/adm.0000000000000760.Peer-Reviewed Original Research
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchAdvancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DeterrentsAlcohol DrinkingAlcoholismFemaleHumansMaleMiddle AgedNaltrexonePrecision MedicineRewardTreatment OutcomeConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinking
2018
Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment
Witkiewitz K, Kirouac M, Roos CR, Wilson AD, Hallgren KA, Bravo AJ, Montes KS, Maisto SA. Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment. Psychology Of Addictive Behaviors 2018, 32: 639-646. PMID: 30160499, PMCID: PMC6136973, DOI: 10.1037/adb0000381.Peer-Reviewed Original ResearchConceptsLow-risk drinkingRisk drinkingHeavy drinkingDrinking daysAlcohol-related consequencesAlcohol usePersistent heavy drinkingWeeks of treatmentOutcomes 3 yearsDrinking outcomesHeavy drinking daysLow-risk drinkersAlcohol use disorderMeasures latent class analysisOutpatient armRisk drinkersOutcome measuresHeavy drinking episodesLower riskUse disordersHeavy drinkersFunctioning outcomesPsychosocial functioningAbstinenceDrinking episodesBroad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation.
Witkiewitz K, Roos CR, Tofighi D, Van Horn ML. Broad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation. Journal Of Studies On Alcohol And Drugs 2018, 79: 199-207. PMID: 29553346, PMCID: PMC6019776, DOI: 10.15288/jsad.2018.79.199.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol DrinkingAlcoholismBehavior TherapyData CollectionFemaleHumansMaleNegotiatingConceptsAlcohol use disorderMedication managementBehavioral interventionsDrinking outcomesOutcomes 12 monthsCombined Behavioral InterventionCombined PharmacotherapiesUse disordersAUD treatmentCoping repertoireCOMBINE StudySecondary analysisSignificant mediatorAlcohol Dependence (COMBINE) StudyBehavioral treatmentIntervention efficacyBroad coping repertoireMultisite studyInterventionGreater likelihoodOutcomesTreatmentMediatorsAlcohol outcomesBehavior change
2017
Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes
Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, Heinz A, Witkiewitz K. Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes. Neuropsychopharmacology 2017, 43: 891-899. PMID: 29154368, PMCID: PMC5809801, DOI: 10.1038/npp.2017.282.Peer-Reviewed Original ResearchConceptsBetter treatment responseAlcohol dependenceTreatment responsePREDICT studyAnalysis of subgroupsSubgroup of individualsRelief scoresActive medicationRandomized trialsAD patientsSelf-report questionnairesMedicationsNaltrexonePharmacotherapy responseHigher effect sizesHeavy drinkingClinical applicabilityCutoff analysisDrinking phenotypesPlaceboPrecision medicineDrinkersPatientsEffect sizeDrinkingHow Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials.
Witkiewitz K, Roos CR, Pearson MR, Hallgren KA, Maisto SA, Kirouac M, Forcehimes AA, Wilson AD, Robinson CS, McCallion E, Tonigan JS, Heather N. How Much Is Too Much? Patterns of Drinking During Alcohol Treatment and Associations With Post-Treatment Outcomes Across Three Alcohol Clinical Trials. Journal Of Studies On Alcohol And Drugs 2017, 78: 59-69. PMID: 27936365, PMCID: PMC5148751, DOI: 10.15288/jsad.2017.78.59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismFemaleHumansMaleRandomized Controlled Trials as TopicTreatment OutcomeYoung AdultConceptsBetter long-term outcomesLong-term outcomesPersistent heavy drinkingLow-risk drinkingPatterns of drinkingHeavy drinkingClinical trialsAlcohol treatmentWorse long-term outcomesDrinking patternsWeeks of treatmentRandomized clinical trialsNon-heavy drinkingRepeated-measures latent class analysisLow-risk drinkersAlcohol use disorderPost-treatment outcomesAlcohol clinical trialsAlcohol Treatment TrialNegative long-term outcomesTreatment trialsWorse outcomesSecondary data analysisUse disordersPatients
2016
Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone
Roos CR, Mann K, Witkiewitz K. Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone. Addiction Biology 2016, 22: 1528-1539. PMID: 27480445, PMCID: PMC5290305, DOI: 10.1111/adb.12427.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment of AUDOpioid receptor antagonistRandomized clinical trialsBetter drinking outcomesGlutamatergic systemSubtypes of individualsReceptor antagonistClinical trialsRewarding effectsUse disordersClinical decisionDrinking outcomesReward drinkersDrinkersNaltrexoneExcellent reliabilityDifferential benefitsDistinct patterns
2015
Drinking Motives Mediate the Negative Associations Between Mindfulness Facets and Alcohol Outcomes Among College Students
Roos CR, Pearson MR, Brown DB. Drinking Motives Mediate the Negative Associations Between Mindfulness Facets and Alcohol Outcomes Among College Students. Psychology Of Addictive Behaviors 2015, 29: 176-183. PMID: 25546142, PMCID: PMC4388773, DOI: 10.1037/a0038529.Peer-Reviewed Original ResearchThe Indirect Effect of the Therapeutic Alliance and Alcohol Abstinence Self‐Efficacy on Alcohol Use and Alcohol‐Related Problems in Project MATCH
Maisto SA, Roos CR, O'Sickey AJ, Kirouac M, Connors GJ, Tonigan JS, Witkiewitz K. The Indirect Effect of the Therapeutic Alliance and Alcohol Abstinence Self‐Efficacy on Alcohol Use and Alcohol‐Related Problems in Project MATCH. Alcohol Clinical And Experimental Research 2015, 39: 504-513. PMID: 25704134, PMCID: PMC4457319, DOI: 10.1111/acer.12649.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTherapeutic allianceCognitive behavioral treatment groupClient ratingsBehavioral treatment groupEffects of therapistSelf-efficacy changeProject MATCH dataAlcohol-related outcomesAUD treatment outcomesTwelve-step facilitationAlcohol abstinencePosttreatment drinking outcomesMotivation enhancementWorking Alliance InventoryModeration effectMediation analysisDrinking outcomesTherapist ratingsStatistical mediatorAUD outcomesAlliance ratingsAlcohol useAlliance InventoryIndirect effects