2017
Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes
Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, Heinz A, Witkiewitz K. Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes. Neuropsychopharmacology 2017, 43: 891-899. PMID: 29154368, PMCID: PMC5809801, DOI: 10.1038/npp.2017.282.Peer-Reviewed Original ResearchConceptsBetter treatment responseAlcohol dependenceTreatment responsePREDICT studyAnalysis of subgroupsSubgroup of individualsRelief scoresActive medicationRandomized trialsAD patientsSelf-report questionnairesMedicationsNaltrexonePharmacotherapy responseHigher effect sizesHeavy drinkingClinical applicabilityCutoff analysisDrinking phenotypesPlaceboPrecision medicineDrinkersPatientsEffect sizeDrinking
2013
Polypharmacy Reduction in Youth in a Residential Treatment Center Leads to Positive Treatment Outcomes and Significant Cost Savings
van Wattum PJ, Fabius C, Roos C, Smith C, Johnson T. Polypharmacy Reduction in Youth in a Residential Treatment Center Leads to Positive Treatment Outcomes and Significant Cost Savings. Journal Of Child And Adolescent Psychopharmacology 2013, 23: 620-627. PMID: 24251644, DOI: 10.1089/cap.2013.0014.Peer-Reviewed Original ResearchConceptsMedication reductionTreatment centersResidential treatment centerTreatment outcomesLong-term treatment outcomesUse of antipsychoticsNumber of antipsychoticsPlace of dischargePositive treatment outcomesAdmission medicationsAntipsychotic combinationsPolypharmacy reductionPostdischarge dataDischarge medicationsMore medicationsAvailable followMonths postdischargeMood stabilizersPolypharmacy regimensMedicationsAdmissionYouth ages 11Mean numberHealthcare systemAntipsychotics