2024
Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence
Votaw V, Tuchman F, Roos C, Hebden H, McKay J, Kiluk B, Witkiewitz K. Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence. Journal Of Substance Use And Addiction Treatment 2024, 163: 209394. PMID: 38735481, PMCID: PMC11180556, DOI: 10.1016/j.josat.2024.209394.Peer-Reviewed Original ResearchCocaine use disorderCocaine useAssociated with less cocaine useTelephone-based continuing careLevel of cocaine useFollow-upDrug use consequencesAssociated with lower levelsClinical trialsBaseline to 12-month follow-upCocaine dependenceTreatment entryProblem severityUse disorderTimeline FollowbackCocaineInitial treatment phaseAbstinenceLow-frequency useLong-term functional outcomeEffect sizeTreatment phaseLong-term outcomesRandomized clinical trialsNegative consequences
2023
Predictors of relapse in eating disorders: A meta-analysis
Sala M, Keshishian A, Song S, Moskowitz R, Bulik C, Roos C, Levinson C. Predictors of relapse in eating disorders: A meta-analysis. Journal Of Psychiatric Research 2023, 158: 281-299. PMID: 36623362, DOI: 10.1016/j.jpsychires.2023.01.002.Peer-Reviewed Original ResearchConceptsPredictors of relapseED relapseStudy-level effect sizesIndividual differencesPotential moderatorsED psychopathologyModerator effectsVariety of variablesHigh motivationED subtypesMultilevel mixed-effects modelsPredictor assessmentED onsetEffect sizeFuture researchMultilevel random effects modelsStrongest predictorModeratorPsychiatric comorbidityMixed effects modelsRandom-effects modelPredictorsDisordersHigher oddsBody fat
2021
Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance users
2017
Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes
Mann K, Roos CR, Hoffmann S, Nakovics H, Leménager T, Heinz A, Witkiewitz K. Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes. Neuropsychopharmacology 2017, 43: 891-899. PMID: 29154368, PMCID: PMC5809801, DOI: 10.1038/npp.2017.282.Peer-Reviewed Original ResearchConceptsBetter treatment responseAlcohol dependenceTreatment responsePREDICT studyAnalysis of subgroupsSubgroup of individualsRelief scoresActive medicationRandomized trialsAD patientsSelf-report questionnairesMedicationsNaltrexonePharmacotherapy responseHigher effect sizesHeavy drinkingClinical applicabilityCutoff analysisDrinking phenotypesPlaceboPrecision medicineDrinkersPatientsEffect sizeDrinking