2021
Reward drinking and naltrexone treatment response among young adult heavy drinkers
Roos CR, Bold KW, Witkiewitz K, Leeman RF, DeMartini KS, Fucito LM, Corbin WR, Mann K, Kranzler HR, O'Malley SS. Reward drinking and naltrexone treatment response among young adult heavy drinkers. Addiction 2021, 116: 2360-2371. PMID: 33620746, PMCID: PMC8328878, DOI: 10.1111/add.15453.Peer-Reviewed Original Research
2020
Approach Coping and Substance Use Outcomes Following Mindfulness-Based Relapse Prevention Among Individuals with Negative Affect Symptomatology
Roos C, Bowen S, Witkiewitz K. Approach Coping and Substance Use Outcomes Following Mindfulness-Based Relapse Prevention Among Individuals with Negative Affect Symptomatology. Mindfulness 2020, 11: 2397-2410. PMID: 33510820, PMCID: PMC7837604, DOI: 10.1007/s12671-020-01456-w.Peer-Reviewed Original ResearchSubstance use disordersAffective symptomsRelapse preventionSubstance-related problemsTherapeutic effectConditional indirect effectsHeavy drinking daysApproach copingAvoidance copingSubstance use outcomesNegative affective symptomsMonth 12Conditional indirect effect modelDrinking daysUse disordersSignificant conditional indirect effectAftercare treatmentSymptomsAffective symptomatologyLatent growth curve analysisIndirect effects modelPTSD symptomsCurve analysisMethodsThe sampleSubstance use
2019
Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response
Witkiewitz K, Roos CR, Mann K, Kranzler HR. Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response. Alcohol Clinical And Experimental Research 2019, 43: 2395-2405. PMID: 31436886, PMCID: PMC6824945, DOI: 10.1111/acer.14183.Peer-Reviewed Original ResearchConceptsEffects of naltrexoneHeavy drinking daysAlcohol use disorderDaily naltrexoneUse disordersDrinking daysDaily drinkingPercent heavy drinking daysPrecision medicinePrecision medicine approachDaily medicationNaltrexone responseInteractive voice response technologyClinical trialsNaltrexone effectsRewarding effectsSpecific treatmentNaltrexoneSecondary analysisMedicine approachDrinkersProblem drinkersReward drinkersPlaceboDrinkingMindfulness‐Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double‐Blind Sham‐Controlled Randomized Trial
Witkiewitz K, Stein ER, Votaw VR, Wilson AD, Roos CR, Gallegos SJ, Clark VP, Claus ED. Mindfulness‐Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double‐Blind Sham‐Controlled Randomized Trial. Alcohol Clinical And Experimental Research 2019, 43: 1296-1307. PMID: 30977904, PMCID: PMC6551269, DOI: 10.1111/acer.14053.Peer-Reviewed Original ResearchConceptsMindfulness-based relapse preventionAlcohol cue reactivityAlcohol use disorderDirect current stimulationCue reactivitySham-controlled randomized trialHeavy drinking daysStop-signal reaction time taskRelapse preventionCurrent stimulationRight inferior frontal gyrusSelf-reported cravingInferior frontal gyrusReaction time taskTranscranial direct current stimulationPercent heavy drinking daysDrinking daysCurrent studyCue taskResponse inhibitionTime taskFrontal gyrusNeurobiological dysfunctionAnodal tDCSGroup treatmentIndividual Gender and Group Gender Composition as Predictors of Differential Benefit from Mindfulness-Based Relapse Prevention for Substance Use Disorders
Roos C, Stein E, Bowen S, Witkiewitz K. Individual Gender and Group Gender Composition as Predictors of Differential Benefit from Mindfulness-Based Relapse Prevention for Substance Use Disorders. Mindfulness 2019, 10: 1560-1567. PMID: 31741686, PMCID: PMC6860023, DOI: 10.1007/s12671-019-01112-y.Peer-Reviewed Original ResearchDrug use daysSubstance use disordersHeavy drinking daysRelapse preventionUse daysMonth 12Therapy groupMore womenUse disordersDrinking daysAftercare treatmentRP groupSecondary data analysisTreatment moderatorsWomenPreventionOne-thirdDaysDisordersDifferential benefitsOutcomesGenderTreatmentAnalysis sampleGroup
2018
Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment
Witkiewitz K, Kirouac M, Roos CR, Wilson AD, Hallgren KA, Bravo AJ, Montes KS, Maisto SA. Abstinence and Low Risk Drinking During Treatment: Association With Psychosocial Functioning, Alcohol Use, and Alcohol Problems 3 Years Following Treatment. Psychology Of Addictive Behaviors 2018, 32: 639-646. PMID: 30160499, PMCID: PMC6136973, DOI: 10.1037/adb0000381.Peer-Reviewed Original ResearchConceptsLow-risk drinkingRisk drinkingHeavy drinkingDrinking daysAlcohol-related consequencesAlcohol usePersistent heavy drinkingWeeks of treatmentOutcomes 3 yearsDrinking outcomesHeavy drinking daysLow-risk drinkersAlcohol use disorderMeasures latent class analysisOutpatient armRisk drinkersOutcome measuresHeavy drinking episodesLower riskUse disordersHeavy drinkersFunctioning outcomesPsychosocial functioningAbstinenceDrinking episodes
2017
Coping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high
Roos CR, Maisto SA, Witkiewitz K. Coping mediates the effects of cognitive–behavioral therapy for alcohol use disorder among out‐patient clients in Project MATCH when dependence severity is high. Addiction 2017, 112: 1547-1557. PMID: 28388836, PMCID: PMC5544539, DOI: 10.1111/add.13841.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTwelve-step facilitationCognitive behavioral therapyMotivational enhancement therapyUse disordersPositive treatment effectDependence severityDrinking outcomesTreatment effectsProject MATCHPercentage days abstinentHeavy drinking daysAlcohol Treatment TrialPrimary outcomeTreatment armsTreatment trialsSecondary data analysisDays abstinentDrinking daysAlcohol Dependence ScaleTherapyPatient samplesEnhancement therapySeverityChange Questionnaire