2019
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes
Sun R, Hedl M, Abraham C. IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes. Gut 2019, 69: 264. PMID: 31097538, PMCID: PMC6858485, DOI: 10.1136/gutjnl-2018-316830.Peer-Reviewed Original ResearchConceptsMonocyte-derived macrophagesHuman monocyte-derived macrophagesJanus kinase/signal transducerKinase/signal transducerDynamin-mediated endocytosisReceptor-induced signalingCell surface regulationR381Q variantIBD pathogenesisIntestinal myeloid cellsLate endosomesPattern recognition receptorsSignal transducerPathway membersDefines mechanismsReal-time PCRCell typesHeLa cellsSignalingKey playersRNA expressionHuman macrophagesPathwayWestern blotMyeloid cells
2012
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 2012, 491: 259-263. PMID: 23075849, PMCID: PMC3493690, DOI: 10.1038/nature11535.Peer-Reviewed Original Research
2011
Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses
Sarin R, Wu X, Abraham C. Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 9560-9565. PMID: 21606346, PMCID: PMC3111257, DOI: 10.1073/pnas.1017854108.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationCells, CulturedFlow CytometryHEK293 CellsHeLa CellsHumansImmunoblottingInflammatory Bowel DiseasesInterferon-gammaInterleukin-17Interleukin-23InterleukinsLuciferasesPolymorphism, Single NucleotideReceptors, InterleukinSignal TransductionSTAT3 Transcription FactorTh17 CellsConceptsT cellsIL-22 productionIL-23 receptorT cell functional responsesMultiple inflammatory diseasesPrimary human CD4WT CD8Tc17 cellsIL-17Arginine alleleInflammatory diseasesReceptor polymorphismsPrimary CD4Transcription 3 (STAT3) activationCD8Human CD4Function alterationsSignificant protectionHuman genetic polymorphismsGenetic polymorphismsR381QCD4AutoimmunityFunctional consequencesSignal transducer